NMN Converts to Nicotinamide Riboside Before Entering Cells: Preclinical Findings

SynopsisNAD+ is an essential molecule that helps enzymes like sirtuins and poly(ADP-ribose) polymerases work properly. Supplements like nicotinamide mononucleotide (NMN) and nicotinamide riboside (...

Nicotinamide Riboside Supports Pancreatic β-Cell Function During Aging and Diet Stress: Preclinical Findings

SynopsisDisturbances in NAD+ metabolism have been linked to many age-related and metabolic diseases like type 2 diabetes. Pancreatic β-cells play a key role in controlling blood sugar, but how NAD+...

Nicotinamide Riboside Shifts Human Fat Cells Toward Energy-Burning Beige Cells: Preclinical Findings

SynopsisBeige fat cells play key roles in organismal energy and metabolic balance. NR supplementation of human white fat cells derived from stem cells induced mitochondrial biogenesis and expressio...

Nicotinamide Riboside Reverses Metabolic Dysfunction in Werner's Syndrome: Preclinical Findings

SynopsisWerner syndrome (WS) features premature aging and metabolic dysfunction, yet mechanisms remain unclear. This study found that loss of the WRN protein accelerates early fat cell formation in...

Nicotinamide Riboside Rejuvenates Aged Hematopoietic Stem Cells and Improves Regeneration: Preclinical Findings

SynopsisWith age, hematopoietic stem cells (HSCs) lose their ability to regenerate and remain quiescent, leading to an expanded stem cell pool that can cause blood disorders. Researchers found that...

Nicotinamide Riboside Reduces Alcohol-Induced Inflammation and Oxidative Stress in Immune Cells: Preclinical Findings

SynopsisMacrophages play an important role in inflammation and oxidative stress caused by alcohol. Researchers studied how nicotinamide riboside (NR), a precursor of NAD+, affects alcohol-induced i...

Nicotinamide Riboside Protects Gut Nerve Health and Improves Gastrointestinal Transit in Diabetes: Preclinical Findings

SynopsisDiabetes causes systemic oxidative stress that often leads to nerve damage in the enteric nervous system, impairing gut motility and causing symptoms such as constipation or diarrhea. Using...

Nicotinamide Riboside Protects Against Diabetic Kidney Disease: Preclinical Findings

SynopsisDiabetic kidney disease (DKD) is a leading cause of kidney failure, linked to inflammation and mitochondrial dysfunction. This study evaluated whether boosting NAD+ metabolism via nicotinam...

Nicotinamide Riboside Protects Against Diabetes and Neuropathy: Preclinical Findings

SynopsisMale C57BL/6J mice fed a high-fat diet (HFD) develop prediabetes with insulin resistance and sensory neuropathy. When given low doses of streptozotocin, these mice model type 2 diabetes (T2...

Nicotinamide Riboside Improves Insulin Resistance by Boosting Mitochondrial Function in Skeletal Muscle: Preclinical Findings

SynopsisHigh-fat diet-induced insulin resistance (IR) in skeletal muscle is linked to mitochondrial dysfunction and oxidative stress. This study assessed whether nicotinamide riboside (NR) could re...

Nicotinamide Riboside Helps Prevent Obesity, Inflammation, and Fibrosis: Preclinical Findings

SynopsisNR supplementation was tested in young and old obese female mice to see if it reduces liver inflammation and fibrosis. In old mice, NR decreased weight gain, fat mass, and improved glucose ...

Nicotinamide Riboside Has Minor Metabolic Benefits in Obesity: Preclinical Findings

SynopsisNicotinamide riboside supplements (NRS) are thought to boost NAD+ levels and mitochondrial function, potentially improving muscle health and energy use. This study tested NRS effects in nor...

Nicotinamide Riboside Has Minor Effect on Energy Metabolism in Obesity: Preclinical Findings

SynopsisNR has been shown to reverse obesity-related health issues in mice, but effects may vary by strain. Researchers compared mildly obese C57BL/6N and C57BL/6J mice on high-fat diets, with or w...

Nicotinamide Riboside Enhances Brain Enzymes to Combat Alzheimer’s Pathology: Preclinical Findings

SynopsisSIRT3 is a mitochondrial enzyme that improves cell function. Deleting SIRT3 causes brain mitochondrial problems and worsens Alzheimer's disease (AD) features in mice, including insulin resi...

Nicotinamide Riboside Dose Improves Metabolic Flexibility: Preclinical Findings

SynopsisMetabolic flexibility—the ability to switch between burning carbs and fats—is a marker of metabolic health. To study NR's effect on this, mice on a mildly obese diet received varying NR dos...

Nicotinamide Riboside Corrects Metabolic Imbalances and Mitochondrial Dysfunction in Citrin Deficiency: Preclinical Findings

SynopsisCitrin deficiency (CD) is a genetic metabolic disorder caused by loss of the mitochondrial transporter CITRIN, which plays a role in the urea cycle and malate–aspartate shuttle. Patients wi...

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase NAD+ Levels: Preclinical Findings

SynopsisEukaryotic cells use multiple molecules as NAD+ precursors, but how they work together is unclear. This study identified dihydronicotinic acid riboside (NARH) as a new NAD+ precursor in liv...

Nicotinamide Riboside Alters Gut Microbiota to Reduce Weight Gain from High-Fat Diet in Mice: Preclinical Findings

SynopsisThe gut microbiome influences energy balance and obesity risk. Nicotinamide riboside (NR), a vitamin B3 form and NAD+ precursor, can reduce weight gain and increase energy use in obese mice...

NAD+ Supports Metabolism in Impaired Urea Cycle: Preclinical Findings

SynopsisProblems in the urea cycle and how they relate to obesity and inflammation are not well understood, partly because classical urea cycle defects are severe and dramatic. To study this, resea...

NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

SynopsisDiabetic peripheral neuropathy involves nerve degeneration linked to low NAD+ levels. Researchers tested whether NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside ...