Nicotinamide Riboside-Containing β-Hydroxybutyrate Supplementation (NHS101) in Children with Multiple Acyl-CoA Dehydrogenase or Pyruvate Dehydrogenase Deficiency: Case Report

Objective To evaluate the efficacy of a new preparation of dextro-β hydroxybutyrate salt mixture containing NR (NHS101) in patients with metabolic disorders affecting energy metabolism, specificall...

Nicotinamide Riboside and Pyruvate Increase Anti-Inflammatory Pathways: Preclinical Findings

Synopsis This study uncovered a previously unknown anti-inflammatory metabolite, homocysitaconate, produced through the interaction of homocysteine and itaconate during inflammation. The enzyme S-...

Maternal Nicotinamide Riboside Supplementation During Pregnancy May Prevent KYNU Deficiency in Newborns: Case Report

Objectives To characterize the clinical, genetic, and biochemical features of KYNU deficiency and evaluate the safety and preliminary efficacy of postnatal nicotinamide and pyridoxine supplementat...

Nicotinamide Riboside Restores Mitochondrial Activity and Thermogenesis in Brown Fat: Preclinical Findings

Synopsis Brown adipose tissue (BAT) depends on NAD+ biosynthesis for healthy mitochondrial function and thermogenesis. Multi-omics analysis of BXD mouse strains showed that BAT NAD+ metabolism str...

Combined Metabolic Activators Improve Brain and Liver Function in Alzheimer's and Parkinson's Disease: Preclinical Findings

Synopsis Mitochondrial dysfunction and metabolic problems are major contributors to neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD). Research shows that combined metabolic...

NAD+ Restores Heart Function in Heart Failure via Ketone Production: Preclinical Findings

Synopsis Heart failure with preserved ejection fraction (HFpEF) is a common form of heart failure with few treatment options. This study found that the heart can make ketones using the enzyme HMGC...

Roseburia hominis and Nicotinamide Riboside Combat Obesity: Preclinical Findings

Synopsis The gut bacterium Roseburia hominis was found to be depleted in obese individuals and negatively correlated with BMI and serum triglycerides. In high-fat diet–fed mice, supplementation wi...

Nicotinamide Riboside Mitigates Diabetes-Related Bone Loss: Preclinical Findings

Synopsis Type 2 diabetes mellitus (T2DM) caused by high-fat diet/streptozotocin treatment led to impaired bone microarchitecture and bone loss in mice, along with metabolic dysfunction. Supplement...

Nicotinamide Riboside Supplementation Reduces Oxidative Stress and Enhances Mitochondrial Function in Chronic Kidney Disease Immune Cells: Clinical Findings

Objectives To investigate the effects of NR and CoQ10 on oxidative stress, inflammation, and mitochondrial function in patients with chronic kidney disease (CKD). Journal Clinical Journal of the A...

NR and Inosine Restore Metabolic Activity in NAXD-Deficient Cells: Preclinical Findings

Synopsis Mutations in the metabolite-repair enzyme NAXD, which normally converts damaged NADHX/NADPHX back into functional cofactors, cause the severe neurometabolic disorder PEBEL2. In human NAXD...

Nicotinamide Riboside Improves Fructose-Induced Lipid Metabolism Disorders: Preclinical Findings

Synopsis This study examined how nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, protects against fat metabolism disorders caused by high fructose intake. Mice given a 20% fructose ...

Ketone Utilization in Heart and Kidney Metabolism with D-βHB Supplementation: Clinical Findings

Objectives To investigate how the heart and kidneys use ketones as an energy source in healthy subjects after short-term fasting (fasted), a Boost® liquid meal (fed), and with or without the consu...

Nicotinamide Riboside Supplementation and Exercise Are Safe and Feasible in Childhood Cancer Survivors: Clinical Findings

Objectives To evaluate the feasibility and efficacy of a remote telehealth exercise program, with or without NR supplementation, on improving glucose homeostasis and muscle health in adult childho...

NAD+ Supports Metabolism in Impaired Urea Cycle: Preclinical Findings

SynopsisProblems in the urea cycle and how they relate to obesity and inflammation are not well understood, partly because classical urea cycle defects are severe and dramatic. To study this, resea...

NAD+ Precursor Supplementation Enhances Metabolic Efficiency and Antibody Production: Preclinical Findings

Synopsis This study explored how NAD+ precursors can enhance productivity in Chinese hamster ovary (CHO) cells, which are widely used to produce therapeutic antibodies. Previous research showed th...

A Novel Ketogenic Diet Reduces Seizure Severity and Prevents Fatty Liver in Epileptogenesis: Preclinical Findings

Synopsis Drug-resistant epilepsy remains difficult to manage, and while the ketogenic diet (KD) can help reduce seizures, its high fat content often causes metabolic side effects and poor patient ...

Treatment with Bezafibrate and Nicotinamide Riboside Temporarily Stabilizes Cardiovascular Health in Complex I Deficiency: Case Report

Objectives To evaluate the effects of high-dose bezafibrate and NR administration in treating an infant with mutations in the ACAD9 gene, resulting in ACAD9-related complex I deficiency. Journal M...

Therapeutic Effects of Nicotinamide Riboside and NMN on Nonalcoholic Fatty Liver Disease (NAFLD): Preclinical Findings

Synopsis This study explored how nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—two vitamin B3–derived NAD+ precursors known for their anti-aging and metabolic benefits—affect th...

Nicotinamide Riboside Prevents Nicotine and Coca-Cola™-Induced Fatty Liver: Preclinical Findings

Synopsis Both nicotine—found in cigarettes and e-cigarettes—and high-fructose corn syrup (HFCS)—a sweetener in many soft drinks—are known to harm liver health. This study tested whether combining ...

Comparative Evaluation of Four NAD+ Precursors in Preventing High-Glucose-Induced Hepatocyte Damage: Preclinical Findings

Synopsis Boosting NAD+ levels is known to protect the liver from metabolic stress, but the effectiveness of different NAD+ precursors—nicotinic acid (NA), niacinamide (NAM), nicotinamide riboside ...