%20is%20a%20common%20liver%20condition%20linked%20to%20obesity%20and%20metabolic%20problems,%20but%20no%20effective%20treatment%20exists.%20Researchers%20tested%20a%20combination%20of%20metabo...){kind=link}
Metabolic Cofactors Including Nicotinamide Riboside Improves Non-Alcoholic Fatty Liver Disease: Preclinical Findings
Synopsis
Non-alcoholic fatty liver disease (NAFLD) is a common liver condition linked to obesity and metabolic problems, but no effective treatment exists. Researchers tested a combination of metabolic cofactors—including precursors for NAD+ and glutathione (a key antioxidant)—in mice fed a diet that causes fatty liver. After 16 weeks on the fatty diet, mice were given either the cofactors or placebo for 4 weeks. Treatment reduced fat buildup in the liver, lowered liver weight and injury markers, decreased inflammation and fibrosis, and improved insulin sensitivity. Gene analyses showed reduced inflammatory and fibrotic signals. These results suggest this multi-ingredient supplement could be a promising therapy for NAFLD.
Journal
Nutrients