Article: Therapeutic Effects of Nicotinamide Riboside and NMN on Nonalcoholic Fatty Liver Disease (NAFLD): Preclinical Findings

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Liver Disease Liver Health Metabolic Health Preclinical

Therapeutic Effects of Nicotinamide Riboside and NMN on Nonalcoholic Fatty Liver Disease (NAFLD): Preclinical Findings

Synopsis

This study explored how nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—two vitamin B3–derived NAD+ precursors known for their anti-aging and metabolic benefits—affect the liver in nonalcoholic fatty liver disease (NAFLD). In mice fed a high-fat diet, both NR and NMN reduced body weight gain, improved blood sugar regulation, lowered fat buildup and oxidative stress in the liver, and improved lipid profiles. Advanced gene and metabolite analyses revealed that NR and NMN changed how the liver processes fatty acids, enhancing pathways for unsaturated fatty acid, arachidonic acid, and linoleic acid metabolism. They increased healthy polyunsaturated fats and promoted fat breakdown by activating cytochrome P450 (CYP450) enzymes. These results show that NR and NMN restore healthy liver metabolism, offering potential nutritional and therapeutic value for treating fatty liver disease and related metabolic disorders.

Journal

Biomedicine & Pharmacotherapy

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