Article: Nicotinamide Riboside Reduces Photo-Induced Hyperpigmentation in Skin Cells: Preclinical Findings

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Preclinical Skin Health

Nicotinamide Riboside Reduces Photo-Induced Hyperpigmentation in Skin Cells: Preclinical Findings

Synopsis

Ultraviolet radiation (UVR) from sunlight is a major environmental factor that causes skin damage, including sunburn, DNA damage, premature aging, and hyperpigmentation. This study explored whether nicotinamide riboside (NR)—a vitamin B3–derived NAD+ precursor—could protect skin cells from UV damage and reduce melanin overproduction. In experiments using melanocytes (B16F10 cells), NR treatment inhibited melanin synthesis and reduced tyrosinase activity, a key enzyme in pigmentation, without altering melanin-related gene expression. In skin keratinocytes (HaCaT cells) exposed to UVB light, NR also lowered the expression of metalloproteinases—enzymes that degrade skin structure—and decreased cell toxicity. These results show that NR helps prevent UV-induced skin damage and reduces hyperpigmentation, suggesting its potential use as a skin-whitening and photoprotective ingredient in cosmetic and dermatological applications.

Journal

Cosmetics

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Liver Disease

Nicotinamide Riboside Prevents Nicotine and Coca-Cola™-Induced Fatty Liver: Preclinical Findings

Synopsis Both nicotine—found in cigarettes and e-cigarettes—and high-fructose corn syrup (HFCS)—a sweetener in many soft drinks—are known to harm liver health. This study tested whether combining ...

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Cardiovascular Health

Nicotinamide Riboside Protects Mitochondria and Mitigates Brain Dysfunction in Chronic Cerebral Hypoperfusion: Preclinical Findings

Synopsis Chronic cerebral hypoperfusion (CCH)—a long-term reduction in blood flow to the brain—is a major cause of vascular dementia (VaD), which leads to memory loss and cognitive decline. This s...

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