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Nicotinamide Riboside Supplementation Enhances Walking Performance in Peripheral Artery Disease: Clinical Findings
Objectives
To assess the effects of NR supplementation alone and in combination with resveratrol on the six-minute walk distance in individuals with peripheral artery disease (PAD).
Journal
Nature Communications
Key Outcomes
- NR supplementation significantly improved treadmill walking time and the six-minute walking distance (by 17.6 meters), a clinically meaningful change.
- NR effectively improved walking performance in individuals with PAD, while resveratrol did not enhance the benefits of NR.
- NR combined with resveratrol did not significantly improve the six-minute walk distance compared to placebo.
Duration
6 months
Dose
1000 mg*
*Patients were given NR (1000 mg) or NR (1000 mg) + Resveratrol (125 mg).
Study Design
Randomized, double-blind, placebo-controlled, phase II study in 90 peripheral artery disease (PAD) patients