Article: Nicotinamide Riboside Supplementation Enhances Walking Performance in Peripheral Artery Disease: Clinical Findings

Cardiovascular Disease Cardiovascular Health Clinical Healthy Aging & Longevity

Nicotinamide Riboside Supplementation Enhances Walking Performance in Peripheral Artery Disease: Clinical Findings

Objectives

To assess the effects of NR supplementation alone and in combination with resveratrol on the six-minute walk distance in individuals with peripheral artery disease (PAD).

Journal

Nature Communications

Key Outcomes

NR supplementation significantly improved treadmill walking time and the six-minute walking distance (by 17.6 meters), a clinically meaningful change.
NR effectively improved walking performance in individuals with PAD, while resveratrol did not enhance the benefits of NR.
NR combined with resveratrol did not significantly improve the six-minute walk distance compared to placebo.

Duration

6 months

Dose

1000 mg*
*Patients were given NR (1000 mg) or NR (1000 mg) + Resveratrol (125 mg).

Study Design

Randomized, double-blind, placebo-controlled, phase II study in 90 peripheral artery disease (PAD) patients

See Published Study

Clinical

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