Article: Niagen® IV (NR IV) Is Safer, Faster, and More Effective Than NAD+ IV at Raising NAD+ Levels

Jun 10, 2024 Clinical Intravenous Pharmacokinetic/Safety

Niagen® IV (NR IV) Is Safer, Faster, and More Effective Than NAD+ IV at Raising NAD+ Levels

Objectives

To assess the safety and efficacy of a single intravenous administration of NR compared to NAD+ and a saline control in terms of whole blood NAD+ changes, tolerable infusion rates, and clinical chemistry safety profiles.

Journal

medRxiv

Key Outcomes

IV NR was safe, well-tolerated, and resulted in fewer and less severe adverse experiences compared to NAD+ IV.
NR IV increased NAD+ levels by 20.7% after three hours, outperforming both IV NAD+ and oral NR supplementation.
IV NR infusion time was 75% shorter than that of IV NAD+.
While IV NAD+ increased white blood cell and neutrophil counts, indicating a potential inflammatory response, IV NR showed no evidence of such a response.

Duration

24 hours

Dose

Single dose of 500 mg

Study Design

Randomized, double-blind, placebo-controlled pilot clinical study in healthy adults. The study included two phases, with data analyzed from 37 participants in the first phase and 16 participants in the second phase.

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