Article: Nicotinamide Mononucleotide and Nicotinamide Riboside Rejuvenate Ovarian Function: Preclinical Findings

PrevNext
Preclinical Reproductive Health

Nicotinamide Mononucleotide and Nicotinamide Riboside Rejuvenate Ovarian Function: Preclinical Findings

Synopsis

As women age, their ovarian function and egg quality decline, partly due to mitochondrial dysfunction—an imbalance between mitochondrial fission and fusion that leads to energy stress and impaired follicle development (folliculogenesis). This study examined how nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—two vitamin B3–derived NAD+ precursors—affect ovarian health in middle-aged rats. Both NR and NMN increased the ovarian index, improved follicle numbers, and normalized the LH/FSH hormone ratio, key indicators of reproductive health. Molecular analysis showed that aging ovaries had excessive mitochondrial fission (linked to fragmentation and dysfunction), but treatment with NR or NMN restored balance by enhancing mitochondrial fusion and SIRT1 expression, a gene involved in energy regulation and longevity. These findings suggest that NR and NMN rejuvenate ovarian mitochondria, alleviate age-related follicular decline, and could potentially support fertility and hormonal balance in aging females.

Journal

Pharmaceutical Research

Share

Read more

Cardiovascular Disease

Effects of Intravenous Nicotinamide Riboside on Doxorubicin-Related Organ Damage: Preclinical Findings

Synopsis Doxorubicin (DOX) is a powerful chemotherapy drug used to treat various cancers, but its use is limited by serious side effects that damage vital organs such as the heart, kidneys, liver,...

Read more
Liver Disease

Nicotinamide Riboside Prevents Nicotine and Coca-Cola™-Induced Fatty Liver: Preclinical Findings

Synopsis Both nicotine—found in cigarettes and e-cigarettes—and high-fructose corn syrup (HFCS)—a sweetener in many soft drinks—are known to harm liver health. This study tested whether combining ...

Read more