Article: Nicotinamide Riboside Improves Vascular and Cognitive Health in Peripheral Artery Disease: Clinical Findings

May 14, 2025 Cardiovascular Disease Cardiovascular Health Clinical

Nicotinamide Riboside Improves Vascular and Cognitive Health in Peripheral Artery Disease: Clinical Findings

Objectives

To investigate the potential for NR to counteract the age-related vascular and cognitive decline in peripheral artery disease (PAD) patients.

Journal

The Journal of Pharmacology and Experimental Therapeutics

Key Outcomes

NR supplementation improved peripheral endothelial function and blood flow to a region of the brain crucial for working memory and executive functioning (left dorsolateral prefrontal cortex).
NR trended towards enhancing cognitive performance and increasing cerebral metabolism, though the cognitive and metabolic findings were not statistically significant.

Duration

4 weeks

Dose

1000 mg

Study Design

Pilot, open-label, single-arm, exploratory clinical study in 8 patients with PAD

See Published Study

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