Article: Nicotinamide Riboside Increases NAD+ Levels and Improves Symptom Recovery in Long COVID: Clinical Findings

Nov 12, 2025 Clinical COVID/Long-COVID Immune Health Neurological Health

Nicotinamide Riboside Increases NAD+ Levels and Improves Symptom Recovery in Long COVID: Clinical Findings

Objectives

To investigate the effects of NR supplementation on NAD+ levels, cognitive function, and long COVID symptoms in non-hospitalized individuals with long COVID.

Journal

The Lancet eClinical Medicine

Key Outcomes

NR was well-tolerated, with no significant difference in adverse effects between the NR and placebo groups.
NR supplementation significantly increased whole blood NAD+ levels, which remained elevated throughout the entire supplementation period.
No significant differences were observed in cognitive outcomes between the NR and placebo groups.
After 10 weeks of NR supplementation, individual improvements were seen in executive function, fatigue, sleep quality, and depressive symptoms (mood).

Duration

24 weeks (with a two-week screening period, a 20-week intervention period, and a two-week follow-up period)

Dose

2000 mg

Study Design

Randomized, double-blind, placebo-controlled, parallel group study of 58 non-hospitalized individuals with long COVID.

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