Nicotinamide Riboside Increases NAD+ Levels and Improves Symptom Recovery in Long COVID: Clinical Findings

Objectives

To investigate the effects of NR supplementation on NAD+ levels, cognitive function, and long COVID symptoms in non-hospitalized individuals with long COVID. 

Journal

The Lancet eClinical Medicine

Key Outcomes

• NR was well-tolerated, with no significant difference in adverse effects between the NR and placebo groups. 
• NR supplementation significantly increased whole blood NAD+ levels, which remained elevated throughout the entire supplementation period.
• No significant differences were observed in cognitive outcomes between the NR and placebo groups.
• After 10 weeks of NR supplementation, individual improvements were seen in executive function, fatigue, sleep quality, and depressive symptoms (mood). 
  

Duration

24 weeks (with a two-week screening period, a 20-week intervention period, and a two-week follow-up period) 

Dose

2000 mg

Study Design

Randomized, double-blind, placebo-controlled, parallel group study of 58 non-hospitalized individuals with long COVID.