Roseburia hominis and Nicotinamide Riboside Combat Obesity: Preclinical Findings

Synopsis

The gut bacterium Roseburia hominis was found to be depleted in obese individuals and negatively correlated with BMI and serum triglycerides. In high-fat diet–fed mice, supplementation with R. hominis prevented weight gain, improved glucose and lipid metabolism, reduced fatty liver, limited white fat expansion, and protected brown fat thermogenic function. Mechanistically, these benefits were partly due to the bacterium’s ability to produce nicotinamide riboside (NR) and activate the SIRT1/mTOR pathway. These findings highlight R. hominis as a promising next-generation probiotic candidate for combating obesity and metabolic disease.

Journal

Gut Microbes