Article: Nicotinamide Riboside Reduces Inflammation in Retinal Degeneration: Preclinical Findings

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Preclinical Sensory (Auditory/Optical)

Nicotinamide Riboside Reduces Inflammation in Retinal Degeneration: Preclinical Findings

Synopsis

Bright light exposure triggers mitochondrial damage in the retina, releasing double-stranded DNA that activates the cGAS-STING inflammatory pathway and drives microglial pyroptosis, accelerating retinal degeneration. In a mouse model of light-induced retinal degeneration, nicotinamide riboside (NR) preserved mitochondrial function, reduced STING activation in microglia, lowered inflammatory signaling, and protected photoreceptors. Use of a STING inhibitor (H151) produced similar benefits, confirming the pathway’s role. These findings show that NR protects retinal structure and function by suppressing cGAS-STING–driven microglial inflammation and pyroptosis, highlighting this pathway as a promising therapeutic target for retinal degeneration.

Journal

Investigative Ophthalmology & Visual Science

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