Nicotinamide Riboside Improved Mood and Behavior in Depression: Preclinical Findings

Synopsis This study found that low levels of NAD+, a molecule essential for brain energy and cell function, may contribute to depression-like symptoms. Mice with reduced activity of the enzyme NAM...

Nicotinamide Riboside Enhances Brain Enzymes to Combat Alzheimer’s Pathology: Preclinical Findings

SynopsisSIRT3 is a mitochondrial enzyme that improves cell function. Deleting SIRT3 causes brain mitochondrial problems and worsens Alzheimer's disease (AD) features in mice, including insulin resi...

NAD+ Depletion Triggers SARM1 Activation and Cell Death, Prevented by PARP Inhibitors: Preclinical Findings

SynopsisSarm1 is a protein that drives programmed axon degeneration by breaking down NAD⁺, but its activity is controlled by NAD+ levels. This study found that in cells treated with the mitochondri...

Early Nicotinamide Riboside Supplementation Shows Promise in an Individual with Ataxia Telangiectasia: Case Report

Objectives To investigate the effects of NR supplementation in a 3.5-year-old male child with ataxia and recurrent bacterial infections. This was a case study of one individual. Journal Neuropedia...

Emerging Role of Nicotinamide Riboside in Health and Diseases: Review

SynopsisAmong NAD⁺ precursors, nicotinamide riboside (NR) stands out for its safety, effectiveness, and oral bioavailability. A newly identified form of vitamin B3, NR boosts NAD+ in cells and has ...

Balancing NAD+ Deficits with Nicotinamide Riboside: Therapeutic Possibilities and Limitations: Review

SynopsisLow NAD+ levels have been linked to many health problems related to aging and lifestyle. Supplements with NAD+ precursors (vitamin B3 forms) may help, and nicotinamide riboside (NR) has sho...

Nicotinamide Riboside Restores NAD+ and Improves Heart and Brain Function in Leigh Syndrome: Preclinical Findings

SynopsisMice lacking the mitochondrial complex I subunit Ndufs4 develop Leigh syndrome (LS), marked by serious brain and heart problems. This study found these mice have slow, irregular heartbeats ...

Nicotinamide Riboside Reduces and Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

SynopsisChemotherapy often causes peripheral neuropathy with no effective treatments. This study showed that NR, which activates the NAD-dependent enzyme SIRT2, prevents and reverses nerve damage c...

Nicotinamide Riboside and Caffeine Partially Increase Energy in Alzheimer’s Disease: Preclinical Findings

Synopsis As people age, levels of NAD+, a key molecule for energy production, decline, and low NAD+ is linked to energy problems in late-onset Alzheimer’s disease (LOAD). This study tested whether...

Nicotinamide Riboside and Pterostilbene Therapy Improves Cell Metabolism and Shows Promise in ALS: Preclinical Findings

Synopsis Researchers studying amyotrophic lateral sclerosis (ALS) found that not all patients share the same metabolic profile, meaning their cells process energy differently. In particular, one s...

Nicotinamide Riboside Prevents Nerve Damage From Toxic Chemicals: Preclinical Findings

Synopsis Organophosphate-induced delayed neuropathy (OPIDN) is a serious condition caused by exposure to certain toxic chemicals, leading to nerve degeneration similar to Wallerian degeneration, w...

Autism-Linked Gene NRXN1 Found to Affect Mitochondrial Energy and Metabolism: Preclinical Findings

Synopsis Autism is often linked to differences in language, social interaction, and repetitive behaviors, but it is increasingly recognized that energy metabolism and mitochondrial dysfunction can...

Nicotinamide Riboside Restores Memory and Protects the Brain After Stroke: Preclinical Findings

Synopsis After a stroke, the brain suffers from a sudden loss of blood flow that damages neurons and causes memory problems. This study found that treating mice with nicotinamide riboside chloride...

Resveratrol and Dimethyl Fumarate Combination Therapy Shows Promise in Friedreich’s Ataxia: Preclinical Findings

Synopsis Friedreich’s ataxia (FA) is a rare inherited disorder that affects the nervous system and heart, with no approved therapies yet. Researchers tested eight compounds—including nicotinamide ...

NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

SynopsisDiabetic peripheral neuropathy involves nerve degeneration linked to low NAD+ levels. Researchers tested whether NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside ...

Nicotinamide Riboside Supplementation Benefits in Early Parkinson's Disease: Clinical Findings

Objectives To assess the safety, tolerability, and cerebral penetration of NR therapy in Parkinson's disease (PD) patients, as well as determine if NR has an impact on their neurometabolic profile...

Nicotinamide Riboside Reduces Chemotherapy-Induced Eye and Body Hypersensitivity: Preclinical Findings

SynopsisChemotherapy often causes dry eye and nerve pain, which may be due to nerve damage. This study treated rats given the chemotherapy drug paclitaxel with nicotinamide riboside (NR). Paclitaxe...

Rare SARM1 Variants Linked to ALS and Motor Nerve Disorders: Preclinical Findings

SynopsisSARM1 is a protein that breaks down NAD+, playing a key role in axon degeneration. Researchers found seven rare SARM1 gene variants in patients with ALS or other motor nerve disorders. Thes...

EPB41L4A-AS1 and Nicotinamide Riboside Support Brain Energy and Slow Aging: Preclinical FIndings

Synopsis The long non-coding RNA EPB41L4A-AS1 helps regulate NAD+ and ATP production in the brain, which are critical for energy and cellular function. In aging and Alzheimer's disease, EPB41L4A-A...

Mitophagy Enhancers, Including Nicotinamide Riboside, Protect Neurons from Tau-Induced Damage in Alzheimer’s Disease: Preclinical Findings

Synopsis In Alzheimer’s disease (AD), abnormal tau proteins damage mitochondria and synapses, leading to impaired energy production and neuron loss. In mouse hippocampal neurons expressing mutant ...