Urolithin A and Nicotinamide Riboside Support Brain Immune Cells and Mitochondrial Health: Preclinical Findings

SynopsisDuring aging, many cellular processes, including DNA repair, energy production, and immune function, become less efficient. This study examined how two natural compounds, Urolithin A (UA) a...

Targeting Autophagy-NAD Pathway Protects Cells in Niemann-Pick Type C1 Disease: Preclinical Findings

SynopsisImpaired autophagy, which leads to the buildup of misfolded proteins and damaged organelles, has been linked to many human diseases. Loss of autophagy in metabolically active cells can caus...

SARM1 Drives Nerve Damage Following Inflammation and Cell Death Signals: Preclinical Findings

SynopsisNeuroinflammation and a type of cell death called necroptosis play big roles in neurodegenerative diseases, often starting with damage to nerve fibers called axons. SARM1 is a key enzyme th...

Rare SARM1 Variants Linked to ALS and Motor Nerve Disorders: Preclinical Findings

SynopsisSARM1 is a protein that breaks down NAD+, playing a key role in axon degeneration. Researchers found seven rare SARM1 gene variants in patients with ALS or other motor nerve disorders. Thes...

NMNAT1 Protects Injured Axons by Preventing SARM1-Induced NAD+ Loss After Injury: Preclinical Findings

SynopsisOverexpression of the NAD+ biosynthesis enzyme NMNAT1 helps protect injured axons. Although it's believed that higher NAD+ levels or lower NMN levels are important for this protection, the ...

Nicotinamide Riboside Supports Brain Health and Reduces Inflammation in Alzheimer’s Disease: Preclinical Findings

SynopsisNicotinamide riboside (NR), a precursor of NAD+, can improve cognitive function and reduce brain inflammation in Alzheimer's disease (AD) mouse models, even without affecting beta-amyloid p...

Nicotinamide Riboside Restores NAD+ and Improves Heart and Brain Function in Leigh Syndrome: Preclinical Findings

SynopsisMice lacking the mitochondrial complex I subunit Ndufs4 develop Leigh syndrome (LS), marked by serious brain and heart problems. This study found these mice have slow, irregular heartbeats ...

Nicotinamide Riboside Restores Mitochondrial Function in Alpers’ Syndrome: Preclinical Findings

SynopsisAlpers' syndrome is a devastating early-onset neurodegenerative disorder caused by POLG mutations impairing mitochondrial DNA replication. Patient-derived iPSCs were used to create brain or...

Nicotinamide Riboside Reduces Chemotherapy-Induced Eye and Body Hypersensitivity: Preclinical Findings

SynopsisChemotherapy often causes dry eye and nerve pain, which may be due to nerve damage. This study treated rats given the chemotherapy drug paclitaxel with nicotinamide riboside (NR). Paclitaxe...

Nicotinamide Riboside Reduces and Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

SynopsisChemotherapy often causes peripheral neuropathy with no effective treatments. This study showed that NR, which activates the NAD-dependent enzyme SIRT2, prevents and reverses nerve damage c...

Nicotinamide Riboside Protects Retinal Nerve Cells in Glaucoma: Preclinical Findings

SynopsisGlaucoma causes progressive retinal ganglion cell (RGC) degeneration and vision loss, often associated with elevated intraocular pressure (IOP). This study tested whether oral administratio...

Nicotinamide Riboside Protects Gut Nerve Health and Improves Gastrointestinal Transit in Diabetes: Preclinical Findings

SynopsisDiabetes causes systemic oxidative stress that often leads to nerve damage in the enteric nervous system, impairing gut motility and causing symptoms such as constipation or diarrhea. Using...

Nicotinamide Riboside Protects Against Diabetes and Neuropathy: Preclinical Findings

SynopsisMale C57BL/6J mice fed a high-fat diet (HFD) develop prediabetes with insulin resistance and sensory neuropathy. When given low doses of streptozotocin, these mice model type 2 diabetes (T2...

Nicotinamide Riboside Improves Social Preference Deficits: Preclinical Findings

SynopsisNAD-derived molecules regulate oxytocin release, which influences social behaviors. This study tested the effects of nicotinamide riboside (NR) supplementation on social interaction in mice...

Nicotinamide Riboside Improves Mitophagy and Reduces Neuroinflammation in Ataxia Telangiectasia: Preclinical Findings

SynopsisIn the premature aging disease ataxia telangiectasia (A-T), cells show mitochondrial dysfunction and a senescence state that causes inflammation (SASP). This is linked to buildup of damaged...

Nicotinamide Riboside Extends Lifespan and Improves Health in Ataxia Telangiectasia Models: Preclinical Findings

SynopsisAtaxia telangiectasia (A-T) is a rare inherited disease causing worsening nerve damage and loss of coordination. It is caused by problems in the ATM gene, which controls how cells repair DN...

Nicotinamide Riboside Enhances Brain Enzymes to Combat Alzheimer’s Pathology: Preclinical Findings

SynopsisSIRT3 is a mitochondrial enzyme that improves cell function. Deleting SIRT3 causes brain mitochondrial problems and worsens Alzheimer's disease (AD) features in mice, including insulin resi...

Nicotinamide Riboside Boosts NAD+, to Reduce Sleep Need and Support Brain Energy: Preclinical Findings

SynopsisNon-rapid eye movement sleep (NREMS) is linked to lower brain glucose use, which slows metabolic reactions involving NAD+. This study tested whether boosting NAD+ with nicotinamide riboside...

Nicotinamide Riboside and Nicotinamide Mononucleotide Restore Nerve Function in Diabetic Neuropathy: Preclinical Findings

SynopsisReduced NAD+ signaling contributes to nerve degeneration in diabetic peripheral neuropathy. Researchers tested NAD+ precursors, nicotinamide riboside and nicotinamide mononucleotide, in cul...

NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

SynopsisDiabetic peripheral neuropathy involves nerve degeneration linked to low NAD+ levels. Researchers tested whether NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside ...