Nicotinamide Riboside Supports Mitochondrial Health and Neurogenesis in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons progressively degenerate, leading to muscle weakness and paralysis. Declines in NAD+ contribute to mitochondrial dysfu...

Increasing NAD+ with Nicotinamide Riboside Protects Neurons in Spinocerebellar Ataxia Type 7: Preclinical Findings

Synopsis Spinocerebellar ataxia type 7 (SCA7) is a genetic disorder that damages the cerebellum and impairs movement. Researchers found that in SCA7 mice, key genes controlling calcium in cerebell...

Nicotinamide Riboside Protects Against Alcohol-Induced Depression via the Gut-Brain Axis: Preclinical Findings

Synopsis The gut microbiome influences brain health and mood, and nicotinamide riboside (NR) has shown neuroprotective effects. This study tested whether NR could prevent alcohol-induced depressio...

Nicotinamide Ribosides Improves Aerobic Performance: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a form of vitamin B3 that helps increase NAD+ and improve mitochondrial function, but its effect on physical fitness is unclear. In a study with sedentary an...

Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice: Preclinical Findings

Synopsis This study tested whether nicotinamide riboside (NR) can reduce brain inflammation and improve cognitive function in diabetic mice. Mice with diet- and chemically-induced diabetes were gi...

Nicotinamide Riboside Reduces Liver Fibrosis: Preclinical Findings

Synopsis Liver fibrosis is part of the non-alcoholic fatty liver disease (NAFLD) spectrum, which currently has no approved pharmacological treatment. Researchers tested whether nicotinamide ribosi...

Mild Vitamin B3 Deficiency Changes Gene Activity in White Fat Tissue: Preclinical Findings

Synopsis Mild vitamin B3 (niacin) deficiency is hard to detect. This study compared mice fed a diet without NR (vitamin B3 precursor) to those given recommended B3 levels, both with low tryptophan...

Nicotinamide Riboside Protects Against Liver Fibrosis: Preclinical Findings

Synopsis Nicotinamide riboside (NR) boosts NAD+ levels and offers protective effects in various diseases, but its role in liver fibrosis is unclear. This study tested NR’s ability to protect again...

Nicotinamide Riboside Enhances Blood Stem Cell Recovery and Regeneration: Preclinical Findings

Synopsis Recent studies show that increased mitochondrial activity and impaired stress response harm hematopoietic stem cells (HSCs), reducing their ability to regenerate. This study found that NR...

Nicotinamide Riboside Protects Motor Neurons in ALS: Preclinical Findings

Synopsis Sirtuins (SIRTs) are enzymes that rely on NAD+ and help regulate DNA repair, metabolism, and oxidative stress. Boosting NAD+ levels can activate SIRTs and antioxidant proteins, reducing m...

Nicotinamide Riboside and Pterostilbene Slow Disease Progression in ALS Patients: Clinical Findings

Objectives To assess the safety, tolerability, and efficacy of nicotinamide riboside and pterostilbene (NRPT) supplementation in people with amyotrophic lateral sclerosis (ALS). Journal Amyotrophi...

Maternal Nicotinamide Riboside Supplementation Supports Postpartum Recovery and Offspring Brain Health: Preclinical Findings

Synopsis Metabolic stress can disrupt the balance of NAD+ molecules in the body. Nicotinamide riboside (NR) helps restore NAD+ levels and protect against such stress. This study tested whether NAD...

Nicotinamide Riboside Improves Memory and Brain Health in Alzheimer's Disease and Aging: Preclinical Findings

Synopsis Increasing NAD+ levels to repair damaged mitochondria is a promising strategy for treating Alzheimer’s disease (AD) and other forms of dementia. Nicotinamide riboside (NR) is a safe NAD+ ...

Nicotinamide Riboside Restores NAD+ Levels and Improves Heart Function in Cardiomyopathy: Preclinical Findings

Synopsis Cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy) leads to heart muscle and electrical dysfunction, often resulting in heart failure. Currently, there is no t...

The Effects of NAD+ Boosting in Mitochondrial DNA Depletion Syndrome: Preclinical Findings

Synopsis Patients with mtDNA depletion syndrome 3 (MTDPS3) often die young from liver failure due to severely reduced mitochondrial DNA. Research into treatments has been difficult because MTDPS3 ...

Nicotinamide Riboside Prevents SARM1-Induced NAD+ and ATP Depletion: Preclinical Findings

Synopsis Mitochondrial dysfunction is a key feature of neurodegenerative diseases like Parkinson’s. SARM1 promotes nerve damage by breaking down NAD+, and its activity is increased when phosphoryl...

L-Glutamine and Nicotinamide Riboside Supplementation in Congenital Glutamine Synthetase Deficiency: Case Study

Objectives To assess the clinical and biochemical efficacy of L-glutamine and NR supplementation in a child with congenital GS deficiency. Journal Neuropediatrics Key Outcomes Treatment with L-gl...

Preventing NMN Accumulation Protects Nerves from Chemotherapy-Induced Damage: Preclinical Findings

Synopsis Axon degeneration is a key feature of chemotherapy-induced peripheral neuropathy (CIPN). While it has been linked to loss of NAD+ via SARM1, recent evidence suggests that a buildup of NMN...

Nicotinamide Riboside Reduces Amyloid Plaque Formation and Improves Contextual Memory in Alzheimer's Disease: Preclinical Findings

Synopsis Alzheimer’s disease (AD) is a devastating neurodegenerative disorder driven by the accumulation of toxic amyloid-β (Aβ) protein aggregates. This study identifies a conserved mitochondrial...

SARM1 Enzyme Drives Axonal NAD+ Loss and Degeneration: Preclinical Findings

Synopsis Axonal degeneration, or the breakdown of nerve fibers, happens early in many neurological diseases. The protein SARM1 is a key driver of this process, causing axons to lose NAD+, a vital ...