Nicotinamide Riboside and Nicotinamide Mononucleotide Restore Nerve Function in Diabetic Neuropathy: Preclinical Findings

SynopsisReduced NAD+ signaling contributes to nerve degeneration in diabetic peripheral neuropathy. Researchers tested NAD+ precursors, nicotinamide riboside and nicotinamide mononucleotide, in cul...

Nicotinamide Riboside Boosts NAD+, to Reduce Sleep Need and Support Brain Energy: Preclinical Findings

SynopsisNon-rapid eye movement sleep (NREMS) is linked to lower brain glucose use, which slows metabolic reactions involving NAD+. This study tested whether boosting NAD+ with nicotinamide riboside...

Combination Therapy with Nicotinamide Riboside, Pterostilbene, and Ibudilast Protects Motor Neurons and Prolongs Survival in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by oxidative stress, inflammation, and the progressive death of motor neurons. This study tested a triple t...

High-Dose Nicotinamide Riboside Supplementation Provides Benefits in Parkinson’s Disease: Clinical Findings

Objectives To assess the safety of high-dose NR through the absence of clinically significant adverse events, and assess short-term tolerability and impacts on NAD+, as well as clinical severity o...

Nicotinamide Riboside Supplementation in Mild Cognitive Impairment: Clinical Findings

Objectives To determine the safety of oral NR supplementation in older adults with mild cognitive impairment (MCI), and investigate its effects on cognition, brain volume and functioning, and phys...

Nicotinamide Riboside Supplementation in a Child with Mitochondrial Variant and MELAS-Like Symptoms: Case Report

Objectives To assess the potential efficacy of NR supplementation as a therapeutic intervention for a child carrying the mitochondrial DNA variant m.12315G>A, which has previously been identifi...

Nicotinamide Riboside Improves Inflammation-Induced Chronic Pain | Preclinical Findings

Synopsis Many patients continue to feel pain even after inflammation has healed, but the reason has been unclear. This study found that mitochondrial dysfunction in sensory neurons—the nerve cells...

Nicotinamide Riboside Supplementation Improves Motor Coordination and Eye Movements in Children with Ataxia Telangiectasia: Clinical Findings

Objectives To examine the safety and efficacy of long-term NR supplementation on neuromotor function in patients with ataxia telangiectasia (AT). Journal Movement Disorders Key Outcomes Long-ter...

Effect of the Mediterranean Diet Supplemented with Nicotinamide Riboside, Pterostilbene, and/or Coconut Oil in ALS Patients: Pilot Clinical Findings

Objectives To assess the effects of a Mediterranean diet supplemented with nicotinamide riboside (NR) and pterostilbene, with or without coconut oil, on body weight, composition, BMI, and overall ...

Clinical Outcomes of SAMe and Nicotinamide Riboside Supplementation in a Child with Arts Syndrome: Case Report

Objectives To examine the effects of supplementation of S-adenosylmethionine (SAMe) and NR in a child with Arts syndrome and compare to previous Arts syndrome patients who received SAMe with or wi...

Nicotinamide Riboside Protects Retinal Nerve Cells in Glaucoma: Preclinical Findings

SynopsisGlaucoma causes progressive retinal ganglion cell (RGC) degeneration and vision loss, often associated with elevated intraocular pressure (IOP). This study tested whether oral administratio...

Nicotinamide Riboside Protects Against Neurotoxicity in Zebrafish: Preclinical Findings

Synopsis Decabromodiphenyl ethane (DBDPE) is a new flame retardant that is increasingly found in the environment and living organisms. Its harmful effects on biology are known, but the exact mecha...

Nicotinamide Riboside Protects Spinal Cord Tissue and Recovery After Injury: Preclinical Findings

Synopsis After a spinal cord injury (SCI), tissue damage continues to spread beyond the original site, worsening nerve loss and impairing movement. One major factor driving this damage is the rapi...

Nicotinamide Riboside Improves Social Preference Deficits: Preclinical Findings

SynopsisNAD-derived molecules regulate oxytocin release, which influences social behaviors. This study tested the effects of nicotinamide riboside (NR) supplementation on social interaction in mice...

Nicotinamide Riboside Supplementation Does Not Disrupt Methylation, Including in Individuals with MTHFR Mutations: Clinical Findings

Objectives To investigate the impact of NR supplementation on DNA methylation patterns in the blood cells and muscle tissues of newly diagnosed, dopaminergic treatment-naïve Parkinson's disease (P...

Nicotinamide Riboside Protects Gut Nerve Health and Improves Gastrointestinal Transit in Diabetes: Preclinical Findings

SynopsisDiabetes causes systemic oxidative stress that often leads to nerve damage in the enteric nervous system, impairing gut motility and causing symptoms such as constipation or diarrhea. Using...

Timing of NAD+ Precursors Determines Neuroprotection After Stroke: Preclinical Findings

Synopsis Researchers studying nicotinamide riboside (NR) and nicotinamide (NAM)—both vitamin B3-based NAD+ boosters—found that the timing of supplementation plays a critical role in brain recovery...

Nicotinamide Riboside Supplementation Combined with Metabolic Activators Improves Cognitive Function in Alzheimer’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of L-carnitine tartrate, nicotinamide riboside (NR), serine, and N-acetyl-L-cysteine (NAC), coul...

Combined Metabolic Activators Including Nicotinamide Riboside Improve Metabolism in Alzheimer's and Parkinson's Disease: Preclinical Findings

Synopsis Neurodegenerative diseases like Alzheimer’s disease (AD) and Parkinson’s disease (PD) are linked to metabolic problems, including mitochondrial dysfunction. This study analyzed human brai...

Nicotinamide Riboside Supplementation Raises NAD+ and Lowers Alzheimer's-Associated Biomarkers: Clinical Findings

Objectives To evaluate if NR could augment neuronal NAD+ levels and impact markers of neurodegeneration and insulin-signaling in plasma-derived human neuronal extracellular vesicles (NEVs). Journa...