Nicotinamide Riboside Blocks LPS-Induced Microglial Inflammation: Preclinical Findings

Synopsis In LPS-stimulated BV2 microglia, nicotinamide riboside (NR) restored mitochondrial function and reduced inflammation by activating the AMPK–SIRT3 signaling axis. NR shifted microglia from...

Urolithin A and Nicotinamide Riboside Support Brain Immune Cells and Mitochondrial Health: Preclinical Findings

SynopsisDuring aging, many cellular processes, including DNA repair, energy production, and immune function, become less efficient. This study examined how two natural compounds, Urolithin A (UA) a...

Nicotinamide Riboside Protects Dopamine Neurons in Parkinson's Disease: Preclinical Findings

Synopsis This study identified the essential role of NAMPT, an enzyme that helps produce NAD+, in protecting dopaminergic neurons—the brain cells that control movement and are lost in Parkinson’s ...

Nicotinamide Riboside Protects Brain Development from Drug Toxicity: Preclinical Findings

Synopsis This study explored the potential neurodevelopmental risks of oseltamivir phosphate (OSE)—a widely used antiviral drug also found in the environment—using zebrafish models. Researchers di...

Low NMNAT2 Triggers SARM1 Activity and Alters Nicotinamide Riboside Response in Axons: Preclinical Findings

SynopsisNMNAT2 is a key protein that keeps axons healthy by blocking the pro-degenerative protein SARM1. Completely losing NMNAT2 in mice causes severe axon loss and early death, but removing SARM1...

Nicotinamide Riboside Supports Brain Health and Reduces Inflammation in Alzheimer’s Disease: Preclinical Findings

SynopsisNicotinamide riboside (NR), a precursor of NAD+, can improve cognitive function and reduce brain inflammation in Alzheimer's disease (AD) mouse models, even without affecting beta-amyloid p...

Nicotinamide Riboside Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

Synopsis Paclitaxel (PTX) is a widely used chemotherapy drug for cancers such as breast, lung, and ovarian cancer, but one of its major side effects is chemotherapy-induced peripheral neuropathy (...

Nicotinamide Riboside Supplementation Increases Brain NAD+ Levels in Humans: Clinical Findings

Objectives To investigate the effects of acute NR supplementation on cerebral NAD+ levels in the healthy human brain using a specialized MRI technique called downfield proton magnetic resonance sp...

Nicotinamide Riboside Extends Lifespan and Restores Cardiac Function in Friedreich’s Ataxia: Preclinical Findings

Synopsis Friedreich’s ataxia (FRDA) is a rare inherited disease caused by reduced production of frataxin, a mitochondrial protein essential for iron-sulfur cluster formation. The condition leads t...

Nicotinamide Riboside Reduces Oxidative Stress in Alzheimer's Disease: Preclinical Findings

Synopsis Mitophagy—the process by which damaged mitochondria are removed—is essential for maintaining brain cell health and preventing neurodegeneration. In this study, researchers examined fibrob...

Effects of Nicotinamide Riboside on Mitochondrial Health and Dopamine in Parkinson's Disease: Preclinical Findings

SynopsisParkinson's disease (PD) involves mitochondrial dysfunction, reduced proteasome activity, and dopamine depletion. NR activated mitochondrial function in C. elegans, rescuing α-synuclein-rel...

Nicotinamide Riboside Promotes Spinal Cord Repair: Preclinical Findings

Synopsis Repairing the spinal cord after injury is extremely difficult because nerve cells do not easily regenerate. One promising strategy is to activate endogenous neural stem cells (NSCs)—the b...

Nicotinamide Riboside Improves Survival and Motor Function in Parkinson’s Disease: Preclinical Findings

Synopsis Parkinson’s disease (PD) is a neurodegenerative disorder marked by the loss of dopamine-producing neurons, leading to motor dysfunction and other symptoms. This study investigated how nic...

A Novel Ketogenic Diet Reduces Seizure Severity and Prevents Fatty Liver in Epileptogenesis: Preclinical Findings

Synopsis Drug-resistant epilepsy remains difficult to manage, and while the ketogenic diet (KD) can help reduce seizures, its high fat content often causes metabolic side effects and poor patient ...

Targeting Autophagy-NAD Pathway Protects Cells in Niemann-Pick Type C1 Disease: Preclinical Findings

SynopsisImpaired autophagy, which leads to the buildup of misfolded proteins and damaged organelles, has been linked to many human diseases. Loss of autophagy in metabolically active cells can caus...

Nicotinamide Riboside Protects Mitochondria and Mitigates Brain Dysfunction in Chronic Cerebral Hypoperfusion: Preclinical Findings

Synopsis Chronic cerebral hypoperfusion (CCH)—a long-term reduction in blood flow to the brain—is a major cause of vascular dementia (VaD), which leads to memory loss and cognitive decline. This s...

Liposome Encapsulation Improves Brain Delivery and Neuroprotective Efficacy of Nicotinamide Riboside in Cerebral Ischemia: Preclinical Findings

Synopsis Although nicotinamide riboside (NR), a vitamin B3–derived NAD+ precursor, has proven neuroprotective effects, its poor ability to cross the blood–brain barrier limits its effectiveness in...

Effects of Nicotinamide Riboside on Spinal and Bulbar Muscular Atrophy (SBMA): Preclinical Findings

SynopsisPrevious studies have shown that in spinal and bulbar muscular atrophy (SBMA), a mutant protein called polyQ-expanded AR becomes improperly acetylated, and activating SIRT1, an NAD-dependen...

Nicotinamide Riboside Attenuates Inflammation and Promotes Functional Recovery After Spinal Cord Injury: Preclinical Findings

Synopsis After a spinal cord injury (SCI), levels of nicotinamide adenine dinucleotide (NAD+)—a vital molecule for energy metabolism and cell repair—drop significantly, contributing to inflammatio...

Nicotinamide Riboside Restores Mitochondrial Function in Alpers’ Syndrome: Preclinical Findings

SynopsisAlpers' syndrome is a devastating early-onset neurodegenerative disorder caused by POLG mutations impairing mitochondrial DNA replication. Patient-derived iPSCs were used to create brain or...