NAD+ Depletion Triggers SARM1 Activation and Cell Death, Prevented by PARP Inhibitors: Preclinical Findings

SynopsisSarm1 is a protein that drives programmed axon degeneration by breaking down NAD⁺, but its activity is controlled by NAD+ levels. This study found that in cells treated with the mitochondri...

NAD+ Deficiency Drives Kidney Dysfunction in Cockayne Syndrome: Preclinical Findings

SynopsisCockayne Syndrome (CS) is a premature aging disorder caused by mutations in the CSA and CSB genes, leading to problems like early aging, nerve damage, and kidney dysfunction. Cells from CS ...

Mitochondrial Dysfunction Linked to NAD+ Decline and DNA Repair Dysfunction: Preclinical Findings

SynopsisMitochondrial problems are common in aging and neurodegenerative diseases. In xeroderma pigmentosum group A (XPA), a disease caused by faulty DNA repair that leads to severe neurodegenerati...

Low NMNAT2 Triggers SARM1 Activity and Alters Nicotinamide Riboside Response in Axons: Preclinical Findings

SynopsisNMNAT2 is a key protein that keeps axons healthy by blocking the pro-degenerative protein SARM1. Completely losing NMNAT2 in mice causes severe axon loss and early death, but removing SARM1...

Ketogenic Diet and Nicotinamide Riboside Improve Brain Energy Metabolism in Alzheimer's Disease: Preclinical Findings

SynopsisAlzheimer's disease (AD) impairs brain energy metabolism and mitochondrial function, with potential differences between males and females. This study tested whether a ketogenic diet and/or ...

Inhibiting CD38 and Boosting NAD+ with Nicotinamide Riboside Reduces Brain Inflammation: Preclinical Findings

SynopsisNeuroinflammation begins when the brain's innate immune system responds to inflammation. If not properly controlled, this inflammation worsens diseases like multiple sclerosis and Alzheimer...

Effects of Nicotinamide Riboside on Spinal and Bulbar Muscular Atrophy (SBMA): Preclinical Findings

SynopsisPrevious studies have shown that in spinal and bulbar muscular atrophy (SBMA), a mutant protein called polyQ-expanded AR becomes improperly acetylated, and activating SIRT1, an NAD-dependen...

Effects of Nicotinamide Riboside on Mitochondrial Health and Dopamine in Parkinson's Disease: Preclinical Findings

SynopsisParkinson's disease (PD) involves mitochondrial dysfunction, reduced proteasome activity, and dopamine depletion. NR activated mitochondrial function in C. elegans, rescuing α-synuclein-rel...

Cockayne Syndrome Proteins Maintain Mitochondrial Health Through NAD+ Signaling: Preclinical Findings

SynopsisCockayne syndrome (CS) is a rare premature aging disorder involving DNA repair defects and mitochondrial dysfunction. Across human, mouse, and nematode models, mitochondrial dysfunction was...

Changes in NMN/NAD+ Ratio Activates SARM1 to Trigger Nerve Damage: Preclinical Findings

SynopsisAxon degeneration is a key feature of many neurodegenerative diseases. SARM1 is an enzyme that breaks down NAD+ and, when activated, causes axon destruction. The enzyme NMNAT2 normally conv...

Early Nicotinamide Riboside Supplementation Shows Promise in an Individual with Ataxia Telangiectasia: Case Report

Objective To investigate the effects of NR supplementation in a 3.5-year-old male child with ataxia and recurrent bacterial infections. This was a case study of one individual. Key Outcomes NR su...

Nicotinamide Riboside Supplementation Enhances NAD+ Metabolism in Ataxia Telangiectasia: Clinical Findings

Objectives To study the metabolic effects of treatment with NR in a cohort of patients with ataxia-telangiectasia (AT). Journal Metabolites Key Outcomes NR-related pathways and metabolites signif...

Mild Vitamin B3 Deficiency Changes Gene Activity in White Fat Tissue: Preclinical Findings

Synopsis Mild vitamin B3 (niacin) deficiency is hard to detect. This study compared mice fed a diet without NR (vitamin B3 precursor) to those given recommended B3 levels, both with low tryptophan...

Nicotinamide Riboside Enhances Blood Stem Cell Recovery and Regeneration: Preclinical Findings

Synopsis Recent studies show that increased mitochondrial activity and impaired stress response harm hematopoietic stem cells (HSCs), reducing their ability to regenerate. This study found that NR...

Nicotinamide Riboside Restores NAD+ Levels and Improves Heart Function in Cardiomyopathy: Preclinical Findings

Synopsis Cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy) leads to heart muscle and electrical dysfunction, often resulting in heart failure. Currently, there is no t...

Fixing Imbalanced NAD Metabolism Reduces Effects of Telomere Dysfunction: Preclinical Findings

Synopsis Short telomeres cause diseases like dyskeratosis congenita (DC), which lack effective treatments. This study found that cells from DC patients and telomerase-deficient mice have low NAD+ ...

The Effects of Nutraceutical and Drug Cocktails in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy (DMD) causes muscle weakness leading to respiratory failure. Earlier, quercetin showed temporary respiratory benefits in a mouse model. This study tested querc...

Nicotinamide Riboside Reduces Liver Fibrosis: Preclinical Findings

Synopsis Liver fibrosis is part of the non-alcoholic fatty liver disease (NAFLD) spectrum, which currently has no approved pharmacological treatment. Researchers tested whether nicotinamide ribosi...

Nicotinamide Riboside Reduces Chemotherapy-Induced Peripheral Neuropathy and Suppresses Tumor Growth: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a vitamin B3 precursor of NAD+ that blunts diabetic and chemotherapy-induced peripheral neuropathy in preclinical models. This study tested whether NR also r...

Nicotinamide Riboside Protects Against Liver Fibrosis: Preclinical Findings

Synopsis Nicotinamide riboside (NR) boosts NAD+ levels and offers protective effects in various diseases, but its role in liver fibrosis is unclear. This study tested NR’s ability to protect again...