Nicotinamide Riboside Provides Benefit in Amyotrophic Lateral Sclerosis: Preclinical Findings

Synopsis This study explores how boosting nicotinamide adenine dinucleotide (NAD+) metabolism in astrocytes can protect neurons from degeneration in amyotrophic lateral sclerosis (ALS). NAD+ is vi...

Safety Evaluation of Nicotinamide Riboside: Preclinical Findings

SynopsisNicotinamide riboside (NR) is a natural form of vitamin B3 found in small amounts in foods. A synthetic version, Niagen™, was tested for safety using a series of lab and animal studies. The...

Exploring NAD+ Metabolism in Host–Pathogen Interactions: Review

SynopsisNAD+ is found in all living cells and is controlled by its production, recycling, and breakdown. It is already a drug target for diseases like cancer, neurodegeneration, and inflammation, a...

Nicotinamide Ribosides Reverses Fatty Liver Disease: Preclinical Findings

Synopsis Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with no approved drug treatments. This study demonstrates that a high-fat, high-sugar diet reduces ...

Inhibition of NAMPT and CD73 Suppresses Tumor Growth: Preclinical Findings

Synopsis Researchers are exploring new ways to treat ovarian cancer by targeting how tumor cells produce and recycle energy. This study focused on NAD+, a key molecule for cellular metabolism, and...

NAD+ in Aging, Metabolism, and Neurodegeneration: Review

SynopsisNAD+ is a coenzyme essential for energy production, redox reactions, and as a partner for enzymes like sirtuins and PARPs. Its levels change with age, and altering its production or usage c...

Nicotinamide Riboside Reduces Inflammation and Supports Mitochondrial Health: Preclinical Findings

Synopsis Activation of the NLRP3 inflammasome, a key driver of inflammation linked to metabolic dysfunction, can be influenced by nutrient levels and mitochondrial health. In a study of healthy vo...

How NAD+ Recycling Pathways Influence Virulence in Pneumonia Bacteria: Preclinical Findings

SynopsisNAD is an essential molecule found in all living cells. Some bacteria, like Streptococcus pneumoniae, cannot make NAD from scratch and must recycle it by importing related compounds such as...

Nicotinamide Riboside Reduces Liver Inflammation in Diabetes: Preclinical Findings

Synopsis Chronic low-grade inflammation—known as metaflammation—is a key driver of conditions like type 2 diabetes, obesity, and cardiovascular disease. This study investigated whether nicotinamid...

Nicotinamide Riboside Partially Improves Heart Function in Iron-Deficient Conditions: Preclinical Findings

Synopsis Both too much and too little iron can damage the heart, but the way heart cells use iron is not fully understood. In this study, researchers investigated the role of the transferrin recep...

Nicotinamide Riboside and Nicotinic Acid Riboside Production in Human Cells: Preclnical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for energy metabolism and many cell signaling processes, but because it is constantly used and broken down, cells must continuously r...

Nicotinamide Riboside Improves Mitochondrial Function in Mutant Human Cells: Preclinical Findings

Synopsis Mitochondrial disorders are severe genetic conditions that disrupt energy production, and currently, no effective treatments exist. This study explored whether boosting NAD+, a vital mole...

Nicotinamide Riboside Mediates Longevity Benefits of Calorie Restriction: Preclinical Findings

Synopsis Calorie restriction (CR) is known to extend lifespan in yeast, but how this benefit is communicated between cells has remained unclear. In this study, researchers found that while CR does...

Increasing NAD+ with Nicotinamide Riboside Prevents Liver Cancer Driven by URI: Preclinical Findings

Synopsis The molecular causes of liver cancer (hepatocellular carcinoma, HCC) are not fully understood. This study used genetically modified mice to show that when liver cells produce too much of ...

Increasing NAD+ Production in Muscle Alone Does Not Improve Metabolism: Preclinical Findings

SynopsisNicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), precursors of NAD+, are known to help resist metabolic problems caused by high-fat diets partly by boosting oxidative metab...

A High-Fat Diet and Increasing NAD+ Rescues Premature Aging in Cockayne Syndrome: Preclinical Findings

Synopsis Cockayne syndrome (CS) is a rare genetic disorder that causes early aging and progressive brain degeneration due to problems in DNA repair genes (CSA or CSB). In mice with the CSB mutatio...

Human CD157 Enzyme Regulates NAD+ Precursors to Support Metabolism: Preclinical Findings

Synopsis Human CD157 (hCD157) is an enzyme that helps regulate cell metabolism and immune function and may be linked to neurodegenerative and metabolic diseases. Researchers found that hCD157 brea...

Nicotinamide Riboside Improved Endurance in Mitochondrial Disease: Preclinical Findings

Synopsis Mitochondrial disorders are rare but serious diseases caused by defects in the cell’s energy-producing machinery, known as the mitochondrial respiratory chain. These conditions often lead...

Mitochondrial Dysfunction Linked to NAD+ Decline and DNA Repair Dysfunction: Preclinical Findings

SynopsisMitochondrial problems are common in aging and neurodegenerative diseases. In xeroderma pigmentosum group A (XPA), a disease caused by faulty DNA repair that leads to severe neurodegenerati...

Nicotinamide Riboside Transporter Mediates AICAr Uptake in Yeast, But Not Human Cells: Preclinical Findings

Synopsis This study focuses on cellular metabolism and examines how cells take up and respond to a compound called AICAR, which mimics a low-energy state and can slow cell growth. AICAR must enter...