NAD+ in Aging, Metabolism, and Neurodegeneration: Review
Synopsis
NAD+ is a coenzyme essential for energy production, redox reactions, and as a partner for enzymes like sirtuins and PARPs. Its levels change with age, and altering its production or usage can extend both healthspan and lifespan. This review looks at the factors controlling NAD+ and how supplementing with its precursors could be a promising treatment for aging and related disorders, especially neurodegenerative diseases.
JOURNAL
Science