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Article: NAD+ in Aging, Metabolism, and Neurodegeneration: Review

NAD+ in Aging, Metabolism, and Neurodegeneration: Review


Synopsis

NAD+ is a coenzyme essential for energy production, redox reactions, and as a partner for enzymes like sirtuins and PARPs. Its levels change with age, and altering its production or usage can extend both healthspan and lifespan. This review looks at the factors controlling NAD+ and how supplementing with its precursors could be a promising treatment for aging and related disorders, especially neurodegenerative diseases.

JOURNAL

Science

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Healthy Aging & Longevity

NAD+ Metabolism as a Therapeutic Target for Age-Related Metabolic Diseases: Review

SynopsisNAD+ is a central redox cofactor, but its role in activating sirtuins—a family of NAD-dependent proteins that optimize mitochondrial function—has made it a focus of longevity research. Beca...

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Immune Health

Exploring NAD+ Metabolism in Host–Pathogen Interactions: Review

SynopsisNAD+ is found in all living cells and is controlled by its production, recycling, and breakdown. It is already a drug target for diseases like cancer, neurodegeneration, and inflammation, a...

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