Article: Nicotinamide Riboside Transporter Mediates AICAr Uptake in Yeast, But Not Human Cells: Preclinical Findings

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Cellular Health Preclinical

Nicotinamide Riboside Transporter Mediates AICAr Uptake in Yeast, But Not Human Cells: Preclinical Findings

Synopsis

This study focuses on cellular metabolism and examines how cells take up and respond to a compound called AICAR, which mimics a low-energy state and can slow cell growth. AICAR must enter cells and be converted into its active form to have these effects, but the exact transport mechanisms were unclear. Researchers found that in yeast, AICAr, the precursor form of AICAR, is mainly brought into cells by the nicotinamide riboside transporter (Nrt1), while in humans, it enters through purine nucleoside transporters. These differences in how yeast and human cells handle AICAR could influence how this compound—and related drugs—are used in metabolic and cancer therapies, where controlling cell energy balance and growth is critical.

Journal

Journal of Biological Chemistry

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