Exploring NAD+ Metabolism in Host–Pathogen Interactions: Review

Synopsis

NAD+ is found in all living cells and is controlled by its production, recycling, and breakdown. It is already a drug target for diseases like cancer, neurodegeneration, and inflammation, and is increasingly studied in immune responses. Changes in NAD+ levels during infections can affect both host survival and the ability to clear or tolerate pathogens. This review explores how NAD+ can act as a “double-edged sword” in host–pathogen interactions and how adjusting NAD+ metabolism could be used to treat infectious diseases.

JOURNAL

Cellular and Molecular Life Sciences