Article: NMNAT1 Protects Injured Axons by Preventing SARM1-Induced NAD+ Loss After Injury: Preclinical Findings

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Neurological Health Neuropathy Preclinical

NMNAT1 Protects Injured Axons by Preventing SARM1-Induced NAD+ Loss After Injury: Preclinical Findings

Synopsis

Overexpression of the NAD+ biosynthesis enzyme NMNAT1 helps protect injured axons. Although it's believed that higher NAD+ levels or lower NMN levels are important for this protection, the exact mechanism was unclear. By analyzing NAD+ metabolites in healthy and injured mouse nerve cells, researchers found that NMNAT1 does not increase NAD+ production but instead blocks the injury-triggered, SARM1-dependent consumption of NAD+ that causes axon degeneration.

Journal

eLife

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