Article: NAD+ Metabolism: Energy Production, Signaling Pathways, and Therapeutic Potential: Review

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Healthy Aging & Longevity Neurological Health Review Sensory (Auditory/Optical)

NAD+ Metabolism: Energy Production, Signaling Pathways, and Therapeutic Potential: Review

Synopsis

Vitamin B3's active forms, NAD+ and NADP+, are essential for energy metabolism, cell protection, and biosynthesis. Modern research shows that fluctuations in NAD+ metabolism activate signaling enzymes like sirtuins, PARPs, and CD38, which reprogram cell metabolism and can trigger mitochondrial biogenesis. Multiple biosynthetic pathways feed into NAD+, offering therapeutic opportunities for disease treatment. Aging and illness can disrupt NAD+ balance, but replenishment has shown proof-of-concept success in improving or reversing certain conditions, suggesting that targeting NAD+ pathways could yield powerful biomarkers and interventions for health optimization.

JOURNAL

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

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