Article: Nicotinamide Riboside Supplementation Is Orally Bioavailable in Both Mice and Humans: Clinical Findings

Clinical Pharmacokinetic/Safety

Nicotinamide Riboside Supplementation Is Orally Bioavailable in Both Mice and Humans: Clinical Findings

Objectives

To determine the time and dose-dependent effects of NR supplementation on blood NAD+ metabolism in humans.

Journal

Nature Communications

Key Outcomes

Single oral doses of NR significantly and dose-dependently increased NAD+ and related metabolites in peripheral blood mononuclear cells (PBMCs).
Mouse pharmacokinetic data demonstrated that NR increased NAD+ levels better than niacin (NA) and stimulated NAD+ consuming activities in the liver more than nicotinamide (NAM).

Duration

24 hours

Dose

Single doses of: 100 mg
300 mg
1000 mg

Study Design

Randomized, double-blind, single dose, three-arm study in 12 healthy men and women

See Published Study

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Clinical

Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings

Objectives To determine the human pharmacokinetics of NR supplementation and its effect on whole blood nicotinamide adenine dinucleotide (NAD+) levels. Journal PLoS ONE Key Outcomes NR supplement...