Article: The Effects of NAD+ Boosting on Muscle Mitochondrial Function: Clinical Findings

Nov 11, 2019 Clinical Metabolic Health

The Effects of NAD+ Boosting on Muscle Mitochondrial Function: Clinical Findings

Objectives

To determine if NR supplementation in middle-aged, obese, insulin-resistant men affects mitochondrial respiration, content and morphology in skeletal muscle.

Journal

The Journal of Physiology

Key Outcomes

Protein levels of nicotinamide phosphoribosyltransferase (NAMPT), an essential NAD+ biosynthetic enzyme in skeletal muscle, decreased by 14% with NR. However, NR supplementation did not affect NAD+ metabolite concentrations in skeletal muscle.
Respiration, distribution, and quantity of muscle mitochondria were also unaffected by NR.

Duration

12 weeks

Dose

2000 mg

Study Design

Randomized, double-blind, placebo-controlled, parallel assignment study in 40 healthy, obese, sedentary men

See Published Study

Clinical

Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Objectives To establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD+ metabolome and if it can alter muscle mitochondrial bioenergetics. Journal Cell R...