Article: Nicotinamide Riboside and CoQ10 Supplementation May Support Kidney Health in Chronic Kidney Disease: Clinical Findings

Clinical Kidney Disease Metabolic Health

Nicotinamide Riboside and CoQ10 Supplementation May Support Kidney Health in Chronic Kidney Disease: Clinical Findings

Objectives

To examine the effects of NR and coenzyme Q10 (CoQ10) supplementation alone for six weeks on physical endurance, work efficiency, and metabolic profile in chronic kidney disease (CKD) patients.

Journal

JCI Insight

Key Outcomes

NR supplementation showed a trend towards improved energy metabolism and submaximal exercise efficiency, suggesting better carbohydrate utilization for energy.
NR decreased plasma levels of NAD-dependent citric acid cycle intermediates, suggesting improved mitochondrial metabolism.
NR reduced short and medium-chained plasma triglycerides with a high degree of saturation (tightly packed), suggesting favorable changes in lipid metabolism.
CoQ10 reduced certain types of triglycerides and increased plasma free fatty acids.

Duration

6 weeks

Dose

1000 mg*
*Patients were given NR (1000 mg) or CoQ10 (1200 mg).

Study Design

Randomized double-blind, placebo-controlled, crossover study in 25 chronic kidney disease (CKD) patients

See Published Study

Clinical

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Objectives To assess the safety of high-dose NR through the absence of clinically significant adverse events, and assess short-term tolerability and impacts on NAD+, as well as clinical severity ...