Article: Nicotinamide Riboside Enhances SIRT5 Activity to Support Mitochondrial Function: Preclinical Findings

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Cellular Health Preclinical

Nicotinamide Riboside Enhances SIRT5 Activity to Support Mitochondrial Function: Preclinical Findings

Synopsis

Sirtuins are a family of enzymes that depend on NAD+ to regulate key cellular processes such as DNA repair, metabolism, and aging. Among them, SIRT5 plays an important role in protecting the heart and brain and acting as a tumor suppressor, yet its regulation has been poorly understood. This study discovered that nicotinamide riboside (NR)—a vitamin B3–derived NAD+ precursor—acts as a selective allosteric activator of SIRT5, directly enhancing its enzymatic activity. Using molecular and biochemical analyses, researchers identified how NR binds to SIRT5 and boosts its ability to act on specific protein targets. By revealing this unique activation mechanism, the study provides a foundation for developing more potent and selective SIRT5 activators. These compounds could lead to new therapies for metabolic and age-related diseases, including heart disorders, neurodegeneration, and cancer.

Journal

The FEBS Journal

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Clinical

Acute Effects of Combined Metabolic Activators and NAD+ Precursors on NAD+ Metabolites: Clinical Findings

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