Article: Nicotinamide Riboside Protects Against Ovarian Aging: Preclinical Findings

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Preclinical Reproductive Health

Nicotinamide Riboside Protects Against Ovarian Aging: Preclinical Findings

Synopsis

Recent research shows that NAD+, an important molecule for cell health, plays a key role in ovarian aging, but it was unclear how NAD+ made from scratch in the body affects fertility. In middle-aged mice, removing two genes essential for this process, Ido1 or Qprt, lowered ovarian NAD+ levels, leading to fewer eggs, irregular cycles, reduced fertility, and faster ovarian aging. The eggs also had higher oxidative stress and abnormal structures, which reduced fertilization and early embryo development. These problems were linked to changes in mitochondrial function in the ovaries. Giving the mice nicotinamide riboside (NR), an NAD+ booster, improved egg quality and ovarian health. This study highlights that making NAD+ from scratch is crucial for maintaining fertility in middle-aged females.

Journal

Aging Cell

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Bone Health

Nicotinamide Riboside Supports Cartilage Cell Survival and Normal Bone Growth: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is critical for energy metabolism and bone development. Researchers generated mice lacking NAMPT, an essential enzyme in the NAD+ salvage pathway,...

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Cellular Health

Restoring NAD+ with Nicotinamide Riboside Improves Metabolism and Autophagy in DNA Repair Deficiency: Preclinical Findings

SynopsisLoss of Rev1, a DNA repair protein, causes replication stress, mitochondrial dysfunction, and metabolic imbalance. This study found that mouse embryonic fibroblasts lacking Rev1 had altered...

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