Interaction Between Renalase and Molecules to Regulate Cellular Energy: Preclinical Findings

Synopsis Renalase is an enzyme that helps convert unusual forms of NADH and NADPH—called 2- and 6-isomers—back into their normal active forms, NAD+ and NADP+. These unusual forms can block other i...

NMNAT1 Protects Injured Axons by Preventing SARM1-Induced NAD+ Loss After Injury: Preclinical Findings

SynopsisOverexpression of the NAD+ biosynthesis enzyme NMNAT1 helps protect injured axons. Although it's believed that higher NAD+ levels or lower NMN levels are important for this protection, the ...

Quantification of Nicotinamide Riboside, Nicotinamide Mononucleotide, and NAD+ in Human and Donkey Milk: Preclinical Findings

Synopsis Nicotinamide riboside (NR)—the newest identified form of vitamin B3—and its phosphorylated derivative nicotinamide mononucleotide (NMN) are powerful precursors that increase intracellular...

NMN Converts to Nicotinamide Riboside Before Entering Cells: Preclinical Findings

SynopsisNAD+ is an essential molecule that helps enzymes like sirtuins and poly(ADP-ribose) polymerases work properly. Supplements like nicotinamide mononucleotide (NMN) and nicotinamide riboside (...

Nicotinamide Riboside Extends Lifespan and Improves Health in Ataxia Telangiectasia Models: Preclinical Findings

SynopsisAtaxia telangiectasia (A-T) is a rare inherited disease causing worsening nerve damage and loss of coordination. It is caused by problems in the ATM gene, which controls how cells repair DN...

Nicotinamide Riboside Improves Muscle Function and Restores Muscle Mass: Preclinical Findings

SynopsisNAD+ is an essential cofactor for breaking down metabolic fuels in all cells. However, NAD+ availability can become limited in certain tissues during genotoxic stress and natural aging. The...

Nicotinamide Riboside Reduces Liver Inflammation and DNA Damage: Preclinical Findings

Synopsis Obesity increases the risk of liver cancer (hepatocellular carcinoma, HCC), but the exact mechanisms were unclear. This study found that a liver protein called URI links excess nutrients ...

CD38 Causes Age-Related NAD+ Loss and Mitochondrial Dysfunction: Preclinical Findings

SynopsisNAD+ levels decrease with aging and are involved in age-related metabolic decline. To date, the mechanism responsible for the age-related reduction in NAD+ has not been elucidated. This stu...

Nicotinamide Riboside Protects Against Diabetes and Neuropathy: Preclinical Findings

SynopsisMale C57BL/6J mice fed a high-fat diet (HFD) develop prediabetes with insulin resistance and sensory neuropathy. When given low doses of streptozotocin, these mice model type 2 diabetes (T2...

Nicotinamide Riboside Reverses Age-Related Fatty Liver Disease: Preclinical Findings

Synopsis Aging is a major risk factor for non-alcoholic fatty liver disease (NAFLD), but the biological link between the two has remained unclear. This study shows that declining levels of nicotin...

Nicotinamide Riboside Rejuvenates Aged Muscle Stem Cell Function: Preclinical Findings

Synopsis Aging reduces the regenerative capacity of tissues by driving senescence in adult stem cells (SCs), including those that repair muscle, brain, and skin. This study identifies declining le...

Nicotinamide Riboside Is a Key NAD+ Precursor in Cow's Milk: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a recently identified form of vitamin B3 that serves as a natural precursor to NAD+, a vital molecule for energy production and cellular repair. While NR was...

Nicotinamide Riboside Provides Benefit in Amyotrophic Lateral Sclerosis: Preclinical Findings

Synopsis This study explores how boosting nicotinamide adenine dinucleotide (NAD+) metabolism in astrocytes can protect neurons from degeneration in amyotrophic lateral sclerosis (ALS). NAD+ is vi...

Safety Evaluation of Nicotinamide Riboside: Preclinical Findings

SynopsisNicotinamide riboside (NR) is a natural form of vitamin B3 found in small amounts in foods. A synthetic version, Niagen™, was tested for safety using a series of lab and animal studies. The...

Nicotinamide Ribosides Reverses Fatty Liver Disease: Preclinical Findings

Synopsis Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with no approved drug treatments. This study demonstrates that a high-fat, high-sugar diet reduces ...

Inhibition of NAMPT and CD73 Suppresses Tumor Growth: Preclinical Findings

Synopsis Researchers are exploring new ways to treat ovarian cancer by targeting how tumor cells produce and recycle energy. This study focused on NAD+, a key molecule for cellular metabolism, and...

Nicotinamide Riboside Reduces Inflammation and Supports Mitochondrial Health: Preclinical Findings

Synopsis Activation of the NLRP3 inflammasome, a key driver of inflammation linked to metabolic dysfunction, can be influenced by nutrient levels and mitochondrial health. In a study of healthy vo...

How NAD+ Recycling Pathways Influence Virulence in Pneumonia Bacteria: Preclinical Findings

SynopsisNAD is an essential molecule found in all living cells. Some bacteria, like Streptococcus pneumoniae, cannot make NAD from scratch and must recycle it by importing related compounds such as...

Nicotinamide Riboside Reduces Liver Inflammation in Diabetes: Preclinical Findings

Synopsis Chronic low-grade inflammation—known as metaflammation—is a key driver of conditions like type 2 diabetes, obesity, and cardiovascular disease. This study investigated whether nicotinamid...

Nicotinamide Riboside Partially Improves Heart Function in Iron-Deficient Conditions: Preclinical Findings

Synopsis Both too much and too little iron can damage the heart, but the way heart cells use iron is not fully understood. In this study, researchers investigated the role of the transferrin recep...