Nicotinamide Riboside and Nicotinic Acid Riboside Production in Human Cells: Preclnical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for energy metabolism and many cell signaling processes, but because it is constantly used and broken down, cells must continuously r...

Nicotinamide Riboside Improves Mitochondrial Function in Mutant Human Cells: Preclinical Findings

Synopsis Mitochondrial disorders are severe genetic conditions that disrupt energy production, and currently, no effective treatments exist. This study explored whether boosting NAD+, a vital mole...

Nicotinamide Riboside Mediates Longevity Benefits of Calorie Restriction: Preclinical Findings

Synopsis Calorie restriction (CR) is known to extend lifespan in yeast, but how this benefit is communicated between cells has remained unclear. In this study, researchers found that while CR does...

Increasing NAD+ with Nicotinamide Riboside Prevents Liver Cancer Driven by URI: Preclinical Findings

Synopsis The molecular causes of liver cancer (hepatocellular carcinoma, HCC) are not fully understood. This study used genetically modified mice to show that when liver cells produce too much of ...

Increasing NAD+ Production in Muscle Alone Does Not Improve Metabolism: Preclinical Findings

SynopsisNicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), precursors of NAD+, are known to help resist metabolic problems caused by high-fat diets partly by boosting oxidative metab...

A High-Fat Diet and Increasing NAD+ Rescues Premature Aging in Cockayne Syndrome: Preclinical Findings

Synopsis Cockayne syndrome (CS) is a rare genetic disorder that causes early aging and progressive brain degeneration due to problems in DNA repair genes (CSA or CSB). In mice with the CSB mutatio...

Human CD157 Enzyme Regulates NAD+ Precursors to Support Metabolism: Preclinical Findings

Synopsis Human CD157 (hCD157) is an enzyme that helps regulate cell metabolism and immune function and may be linked to neurodegenerative and metabolic diseases. Researchers found that hCD157 brea...

Nicotinamide Riboside Improved Endurance in Mitochondrial Disease: Preclinical Findings

Synopsis Mitochondrial disorders are rare but serious diseases caused by defects in the cell’s energy-producing machinery, known as the mitochondrial respiratory chain. These conditions often lead...

Mitochondrial Dysfunction Linked to NAD+ Decline and DNA Repair Dysfunction: Preclinical Findings

SynopsisMitochondrial problems are common in aging and neurodegenerative diseases. In xeroderma pigmentosum group A (XPA), a disease caused by faulty DNA repair that leads to severe neurodegenerati...

Nicotinamide Riboside Transporter Mediates AICAr Uptake in Yeast, But Not Human Cells: Preclinical Findings

Synopsis This study focuses on cellular metabolism and examines how cells take up and respond to a compound called AICAR, which mimics a low-energy state and can slow cell growth. AICAR must enter...

Newly Discovered NADase Enzyme and Nicotinamide Riboside Regulate NAD+ Levels and Red Blood Cell Production: Preclinical Findings

Synopsis NADases are enzymes that break down NAD+ into smaller molecules, but their exact role isn't clear. This study found a new NADase on the surface of rabbit red blood cell precursors. It is ...

Nicotinamide Riboside Delays Mitochondrial Myopathy Disease Progression: Preclinical Findings

Synopsis Mitochondrial diseases disrupt the body’s ability to produce energy, leading to muscle weakness and other serious health problems. Because these disorders impair the balance of key energy...

NR and NMN Influence NAD+ Metabolism to Improve Anti-Cancer Therapy: Preclinical Findings

Synopsis In human cells, NAD+ is mainly produced through “salvage” pathways that recycle precursors like nicotinamide, nicotinic acid, and nicotinamide riboside (NR). Blocking this process with th...

Nicotinamide Riboside Enhances Mitochondrial Function and Extends Lifespan: Preclinical Findings

Synopsis NAD+ is a vital molecule that maintains metabolic balance and fuels sirtuin enzymes, which help regulate aging and energy use. In this study, researchers found that NAD+ levels decline wi...

Nicotinamide Riboside Improves Memory and Learning in Alzheimer's Disease: Preclinical Findings

Synopsis NAD+ is an important coenzyme that supports energy production in mitochondria and is linked to longevity and protection against Alzheimer’s disease (AD). Its precursor, nicotinamide ribos...

Nicotinamide Riboside Protects Against High-Fat Diet-Induced Obesity: Preclinical Findings

Synopsis NAD+ is a crucial molecule required for the activity of sirtuin enzymes, which regulate energy use and cellular health. Because of this, adjusting NAD+ levels has become an important way ...

Yeast Control NAD+ Levels by Regulating Nicotinamide Riboside and Nicotinic Acid Export: Preclinical Findings

Synopsis NAD+ serves as both a key coenzyme in metabolic reactions and a substrate for enzymes like sirtuins that regulate aging and stress responses. Its synthesis is essential for extending life...

Pathway for Mitochondrial NAD+ Production in Human Cells Revealed: Preclinical Findings

Synopsis NAD⁺ is an essential molecule for cellular energy and signaling, but how it is made and distributed inside human cells is not fully understood. In particular, the source of mitochondrial ...

Nicotinamide Riboside and Nicotinic Acid Riboside Metabolism in Fungi and Mammals: Preclinical Findings

Synopsis NAD+ is an important coenzyme that helps many cellular reactions and supports enzymes like sirtuins, which regulate aging and stress responses. In yeast, adding nicotinamide riboside (NR)...

Gene Identified That Encodes Nicotinamide Riboside Transporter: Preclinical Findings

Synopsis Nicotinamide riboside is a newly identified precursor of NAD+, a vital coenzyme involved in energy metabolism and sirtuin activity. Supplementing yeast with nicotinamide riboside extends ...