Nicotinamide Riboside and Calorie Restriction Improve Gut Microbiota and Reduce Liver Fat and Inflammation: Preclinical Findings

SynopsisMetabolic dysfunction–related fatty liver disease currently has no specific therapy. This study tested nicotinamide riboside (NR) and dietary restriction (DR) in rats with diet-induced obes...

Combination of Metabolic Cofactors and Nicotinamide Riboside Reduces Obesity and Insulin Resistance: Preclinical Findings

SynopsisObesity is a global health problem marked by excessive fat that often leads to metabolic issues like insulin resistance, high blood pressure, abnormal cholesterol levels, and metabolic synd...

Nicotinamide Riboside Helps Prevent Obesity, Inflammation, and Fibrosis: Preclinical Findings

SynopsisNR supplementation was tested in young and old obese female mice to see if it reduces liver inflammation and fibrosis. In old mice, NR decreased weight gain, fat mass, and improved glucose ...

Nicotinamide Riboside Alters Gut Microbiota to Reduce Weight Gain from High-Fat Diet in Mice: Preclinical Findings

SynopsisThe gut microbiome influences energy balance and obesity risk. Nicotinamide riboside (NR), a vitamin B3 form and NAD+ precursor, can reduce weight gain and increase energy use in obese mice...

Nicotinamide Riboside Has Minor Metabolic Benefits in Obesity: Preclinical Findings

SynopsisNicotinamide riboside supplements (NRS) are thought to boost NAD+ levels and mitochondrial function, potentially improving muscle health and energy use. This study tested NRS effects in nor...

Nicotinamide Riboside Has Minor Effect on Energy Metabolism in Obesity: Preclinical Findings

SynopsisNR has been shown to reverse obesity-related health issues in mice, but effects may vary by strain. Researchers compared mildly obese C57BL/6N and C57BL/6J mice on high-fat diets, with or w...

Coronavirus Disrupts NAD+ Metabolism, While Nicotinamide Riboside Decreases Viral Replication: Preclinical Findings

Synopsis Certain enzymes called PARPs, which use NAD+ to modify proteins, play a role in the body’s defense against coronaviruses. Researchers found that SARS-CoV-2 infection increases the levels ...

NAD+ Precursors Nicotinamide Riboside and Nicotinamide Regulate Cardiac Sodium Channels: Preclinical Findings

Synopsis The heart’s electrical activity depends on sodium channels (NaV1.5) and dysfunction can cause dangerous arrhythmias. Researchers studied how NAD+ precursors nicotinamide riboside (NR) and...

Extracellular NAD+ Broken Down by Human Cells to Maintain Intracellular NAD+ Levels: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is vital for cellular energy and signaling, and human cells replenish NAD+ by using extracellular precursors like nicotinamide (NAM), nicotinic ac...

Nicotinamide Riboside Restores Metabolic Balance in Muscle Cells by Reversing NAD+ Depletion: Preclinical Findings

Synopsis Skeletal muscle plays a key role in overall body metabolism, but aging and disease can reduce its ability to function properly. Researchers studied how changes in NAD+ levels affect muscl...

Nicotinamide Riboside Dose Improves Metabolic Flexibility: Preclinical Findings

SynopsisMetabolic flexibility—the ability to switch between burning carbs and fats—is a marker of metabolic health. To study NR's effect on this, mice on a mildly obese diet received varying NR dos...