Article: Nicotinamide Riboside and Calorie Restriction Improve Gut Microbiota and Reduce Liver Fat and Inflammation: Preclinical Findings

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Digestive/Gut Health Liver Health Obesity Preclinical

Nicotinamide Riboside and Calorie Restriction Improve Gut Microbiota and Reduce Liver Fat and Inflammation: Preclinical Findings

Synopsis

Metabolic dysfunction–related fatty liver disease currently has no specific therapy. This study tested nicotinamide riboside (NR) and dietary restriction (DR) in rats with diet-induced obesity. High-fat cafeteria diets caused liver fat buildup, inflammation, and fibrosis, while DR delayed most liver problems. NR specifically reduced liver fat, cholesterol, and collagen buildup and limited harmful gut bacteria. Combining NR with DR also decreased liver size and inflammation. These findings suggest that NR may help protect the liver and support dietary strategies in fatty liver disease.

Journal

Nutrition

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