Article: Nicotinamide Riboside Protects Gut Nerve Health and Improves Gastrointestinal Transit in Diabetes: Preclinical Findings

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Diabetes Metabolic Health Neurological Health Neuropathy Preclinical

Nicotinamide Riboside Protects Gut Nerve Health and Improves Gastrointestinal Transit in Diabetes: Preclinical Findings

Synopsis

Diabetes causes systemic oxidative stress that often leads to nerve damage in the enteric nervous system, impairing gut motility and causing symptoms such as constipation or diarrhea. Using a rat model of type 1 diabetes induced by streptozotocin, this study tested the effects of nicotinamide riboside (NR) treatment on gastrointestinal transit and nerve health. Results showed that NR improved overall gastrointestinal transit and increased the density of nerve ganglia in both small and large intestines, indicating neuroprotection. Fecal microbiota transplants did not replicate these benefits. These findings highlight NR's potential as a therapeutic agent to improve gut motility and protect enteric nerves in diabetic neuropathy.

Journal

Digestive Diseases and Sciences

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