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Timing of NAD+ Precursors Determines Neuroprotection After Stroke: Preclinical Findings
Synopsis
Researchers studying nicotinamide riboside (NR) and nicotinamide (NAM)—both vitamin B3-based NAD+ boosters—found that the timing of supplementation plays a critical role in brain recovery after a stroke. In mice with blocked brain arteries, a single dose of NR or NAM given after the stroke improved brain tissue recovery and neurological function within 72 hours. However, daily doses given before the stroke had the opposite effect, making brain damage worse. The study suggests that while a single post-stroke treatment increases protective molecules like AMPK, PGC-1α, SIRT1, and ATP, repeated pre-treatment disrupts this balance. These results show that NAD+ precursors can be neuroprotective when used after a stroke, but taking them preventively may increase vulnerability to brain injury.
Journal
Journal of Cerebral Blood Flow & Metabolism