Nicotinamide Riboside Supplementation Improves Motor Coordination and Eye Movements in Children with Ataxia Telangiectasia: Clinical Findings

Objectives To examine the safety and efficacy of long-term NR supplementation on neuromotor function in patients with ataxia telangiectasia (AT). Journal Movement Disorders Key Outcomes Long-ter...

Effect of the Mediterranean Diet Supplemented with Nicotinamide Riboside, Pterostilbene, and/or Coconut Oil in ALS Patients: Pilot Clinical Findings

Objectives To assess the effects of a Mediterranean diet supplemented with nicotinamide riboside (NR) and pterostilbene, with or without coconut oil, on body weight, composition, BMI, and overall ...

Nicotinamide Riboside Supplementation Reduces Inflammatory Markers in Immune Cells from Healthy Subjects and Psoriasis Patients: Clinical Findings

Objectives To examine how ex-vivo NR supplementation affects adaptive immunity in CD4+ T cells extracted from healthy subjects and those with mild-moderate psoriasis, and to investigate the in viv...

Acute Effects of Combined Metabolic Activators and NAD+ Precursors on NAD+ Metabolites: Clinical Findings

Objectives To investigate the safety and acute effects of six different combined metabolic activators (CMA) formulations, each containing 1000 mg of one of the following NAD+ precursors: nicotinam...

Nicotinamide Riboside and CoQ10 Supplementation May Support Kidney Health in Chronic Kidney Disease: Clinical Findings

Objectives To examine the effects of NR and coenzyme Q10 (CoQ10) supplementation alone for six weeks on physical endurance, work efficiency, and metabolic profile in chronic kidney disease (CKD) p...

Nicotinamide Riboside Supplementation May Influence Bacterial Composition: Clinical Findings

Objectives To explore the effects of NR supplementation on the gut microbiota composition in humans. Journal npj Aging Key Outcomes NR supplementation did not affect the diversity or abundance of...

Nicotinamide Riboside Supplementation Does Not Disrupt Methylation, Including in Individuals with MTHFR Mutations: Clinical Findings

Objectives To investigate the impact of NR supplementation on DNA methylation patterns in the blood cells and muscle tissues of newly diagnosed, dopaminergic treatment-naïve Parkinson's disease (P...

Nicotinamide Riboside Supplementation Combined with Metabolic Activators Improves Cognitive Function in Alzheimer’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of L-carnitine tartrate, nicotinamide riboside (NR), serine, and N-acetyl-L-cysteine (NAC), coul...

Nicotinamide Riboside Supplementation Increases Muscle Mitochondrial Biogenesis & Gut Health: Clinical Findings

Objectives To investigate the effects of long-term NR supplementation on mitochondrial biogenesis and metabolic health in humans. Journal Science Advances Key Outcomes In the BMI-discordant twin...

Nicotinamide Riboside Supplementation Raises NAD+ and Lowers Alzheimer's-Associated Biomarkers: Clinical Findings

Objectives To evaluate if NR could augment neuronal NAD+ levels and impact markers of neurodegeneration and insulin-signaling in plasma-derived human neuronal extracellular vesicles (NEVs). Journa...

Nicotinamide Riboside and Pterostilbene Reduce Liver Inflammation in NAFLD: Clinical Findings

Objectives To determine the effects of nicotinamide riboside and pterostilbene (NRPT) supplementation on liver fat in adults with non-alcoholic fatty liver disease (NAFLD). Journal Hepatology Key ...

Nicotinamide Riboside Supplementation Is Safe and Well-Tolerated in Heart Failure Patients: Clinical Findings

Objectives To assess the safety and tolerability of NR in patients with Stage C heart failure with reduced ejection fraction (HFrEF). Journal JACC: Basic to Translational Science Key Outcomes Hig...

Nicotinamide Riboside and Pterostilbene Do Not Improve Muscle Recovery: Clinical Findings

Objectives To determine whether nicotinamide riboside and pterostilbene (NRPT) supplementation helps activate muscle stem cells and supports muscle repair after a small, controlled injury in elder...

Nicotinamide Riboside Supplementation Benefits in Early Parkinson's Disease: Clinical Findings

Objectives To assess the safety, tolerability, and cerebral penetration of NR therapy in Parkinson's disease (PD) patients, as well as determine if NR has an impact on their neurometabolic profile...

Nicotinamide Riboside Supplementation Boosts NAD+ and Lowers Inflammatory Immune Signaling in Lupus: Clinical Findings

Objectives To explore the anti-inflammatory effects of NR in monocytes (a type of white blood cell; immune cell) extracted from young, healthy subjects following supplementation. Additionally, the...

Nicotinamide Riboside Supplementation Improves Neurological Scores and Markers of Immune Health in Ataxia Telangiectasia: Clinical Findings

Objectives To investigate the effects of NR supplementation in patients with ataxia telangiectasia (AT). Journal Movement Disorders Key Outcomes NR supplementation improved ataxia scores (SARA an...

Nicotinamide Riboside Supplementation Combined with Other Nutrients Accelerates Recovery in COVID-19 Patients: Clinical Findings

Objectives To investigate supplementation of the combined metabolic activators (CMA), consisting of L-serine, N-acetyl-L-cysteine (NAC), NR, and L-carnitine tartrate for the treatment of patients ...

Nicotinamide Riboside Supplementation Increases Plasma Levels of the Exercise Hormone Fndc5/Irisin: Clinical Findings

Objectives To investigate the effects of NAD-boosting therapy via NR on Fndc5/irisin levels in humans and its potential role in the development and progression of nonalcoholic fatty liver disease ...

The Effects of NAD+ Boosting on Cold-Stimulated Brown Adipose Tissue Activity: Clinical Findings

Objectives To investigate whether NR stimulates brown adipose tissue in humans. Journal The Journal of Clinical Endocrinology & Metabolism Key Outcomes NR supplementation had no effect on col...

Short-Term Nicotinamide Riboside Supplementation Increases Muscle NAD+ Flux: Clinical Findings

Objectives To assess the effects of NR supplementation on whole-body metabolism and exercise-induced mitochondrial signaling in the skeletal muscle of healthy adults. Journal The Journal of Physi...