Nicotinamide Riboside Supplementation Is Safe and Well-Tolerated in Heart Failure Patients: Clinical Findings

Objectives To assess the safety and tolerability of NR in patients with Stage C heart failure with reduced ejection fraction (HFrEF). Journal JACC: Basic to Translational Science Key Outcomes Hig...

Nicotinamide Riboside Supplementation Benefits in Early Parkinson's Disease: Clinical Findings

Objectives To assess the safety, tolerability, and cerebral penetration of NR therapy in Parkinson's disease (PD) patients, as well as determine if NR has an impact on their neurometabolic profile...

Nicotinamide Riboside Supplementation Boosts NAD+ and Lowers Inflammatory Immune Signaling in Lupus: Clinical Findings

Objectives To explore the anti-inflammatory effects of NR in monocytes (a type of white blood cell; immune cell) extracted from young, healthy subjects following supplementation. Additionally, the...

Nicotinamide Riboside Supplementation Improves Neurological Scores and Markers of Immune Health in Ataxia Telangiectasia: Clinical Findings

Objectives To investigate the effects of NR supplementation in patients with ataxia telangiectasia (AT). Journal Movement Disorders Key Outcomes NR supplementation improved ataxia scores (SARA an...

Nicotinamide Riboside Supplementation Combined with Other Nutrients Accelerates Recovery in COVID-19 Patients: Clinical Findings

Objectives To investigate supplementation of the combined metabolic activators (CMA), consisting of L-serine, N-acetyl-L-cysteine (NAC), NR, and L-carnitine tartrate for the treatment of patients ...

Nicotinamide Riboside Supplementation Increases Plasma Levels of the Exercise Hormone Fndc5/Irisin: Clinical Findings

Objectives To investigate the effects of NAD-boosting therapy via NR on Fndc5/irisin levels in humans and its potential role in the development and progression of nonalcoholic fatty liver disease ...

The Effects of NAD+ Boosting on Cold-Stimulated Brown Adipose Tissue Activity: Clinical Findings

Objectives To investigate whether NR stimulates brown adipose tissue in humans. Journal The Journal of Clinical Endocrinology & Metabolism Key Outcomes NR supplementation had no effect on col...

Short-Term Nicotinamide Riboside Supplementation Increases Muscle NAD+ Flux: Clinical Findings

Objectives To assess the effects of NR supplementation on whole-body metabolism and exercise-induced mitochondrial signaling in the skeletal muscle of healthy adults. Journal The Journal of Physi...

Nicotinamide Riboside Supplementation Enhances NAD+ Metabolism in Ataxia Telangiectasia: Clinical Findings

Objectives To study the metabolic effects of treatment with NR in a cohort of patients with ataxia-telangiectasia (AT). Journal Metabolites Key Outcomes NR-related pathways and metabolites signi...

Nicotinamide Riboside Supplementation Reduces Inflammation in Heart Failure Patients: Clinical Findings

Objectives To investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential antiinflammatory effec...

Nicotinamide Riboside Supplementation Combined with Metabolic Cofactors Shows Promise for NAFLD: Clinical Findings

Objectives To assess the tolerability and metabolic effects of combined supplementation with combined metabolic activators (CMA), L-serine, NAC, nicotinamide riboside, and L-carnitine in healthy h...

Nicotinamide Riboside Supplementation with Metabolic Cofactors Reduces Liver Fat in NAFLD Patients: Clinical Findings

Objectives To determine if combined metabolic activator supplementation (CMA) will reduce hepatic fat in nonalcoholic fatty liver disease (NAFLD) patients. Journal Molecular Systems Biology Key O...

Nicotinamide Riboside Supplementation Modestly Improves Body Composition & Sleeping Metabolic Rate: Clinical Findings

Objectives To investigate the effects of NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers. Journal The Am...

The Effects of NAD+ Boosting on Muscle Mitochondrial Function: Clinical Findings

Objectives To determine if NR supplementation in middle-aged, obese, insulin-resistant men affects mitochondrial respiration, content and morphology in skeletal muscle. Journal The Journal of Phys...

Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Objectives To establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD+ metabolome and if it can alter muscle mitochondrial bioenergetics. Journal Cell R...

The Effects of NAD+ Boosting on Glucose Metabolism or Hormone Response: Clinical Findings

Objectives To test whether NAD+ precursor supplementation with NR affects β-cell function, α-cell function, and incretin hormone secretion as well as circulating bile acid levels in humans. Journa...

Nicotinamide Riboside Supplementation Increases NAD+ Levels in Humans: Clinical Findings

Objectives To evaluate the safety and efficiacy of NR supplementation in overweight, but otherwise healthy men and women. Journal Scientific Reports Key Outcomes NR supplementation significantly ...

High-Dose Nicotinamide Riboside Supplementation Is Safe and Effective: Clinical Findings

Objectives To test the safety of NR supplementation and its potential to improve insulin sensitivity and other metabolic parameters in obese, insulin-resistant men. Journal The American Journal of...

Nicotinamide Riboside Supplementation Safely Boosts NAD+ in Middle-Aged and Older Adults: Clinical Findings

Objectives To assess the tolerability and efficacy of chronic NR supplementation on increasing NAD+ levels in healthy middle-aged and older adults. Journal Nature Communications Key Outcomes NR ...

Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings

Objectives To determine the human pharmacokinetics of NR supplementation and its effect on whole blood nicotinamide adenine dinucleotide (NAD+) levels. Journal PLoS ONE Key Outcomes NR supplement...