Article: Nicotinamide Riboside Supplementation Increases Muscle Mitochondrial Biogenesis & Gut Health: Clinical Findings

Jan 13, 2023 Clinical Digestive/Gut Health Muscle Health

Nicotinamide Riboside Supplementation Increases Muscle Mitochondrial Biogenesis & Gut Health: Clinical Findings

Objectives

To investigate the effects of long-term NR supplementation on mitochondrial biogenesis and metabolic health in humans.

Journal

Science Advances

Key Outcomes

In the BMI-discordant twin pairs, NR supplementation was well-tolerated and increased whole blood NAD+ levels.
NR also increased muscle mitochondrial biogenesis and improved gut microbiota composition, as seen through an increase in the abundance of Faecalibacterium prausnitzii—one of the most beneficial bacteria found in the microbiome of healthy humans.

Duration

5 months

Dose

1000 mg

Study Design

Nonrandomized, open-label, parallel-assignment study in 20 BMI-discordant (one leaner, one heavier) identical twin pairs

See Published Study

Cancer

Nicotinamide Riboside Restores NAD+ and Counters Tumor Hyperprogression: Preclinical Findings

Synopsis Immune checkpoint blockade (ICB) therapy can sometimes cause tumors to grow faster, a problem called hyperprogressive disease (HPD). This study found that when immune cells release interf...

Alzheimer's Disease

Nicotinamide Riboside Supplementation Combined with Metabolic Activators Improves Cognitive Function in Alzheimer’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of L-carnitine tartrate, nicotinamide riboside (NR), serine, and N-acetyl-L-cysteine (NAC), coul...