Nicotinamide Riboside Supplementation Enhances NAD+ Metabolism in Ataxia Telangiectasia: Clinical Findings

Objectives To study the metabolic effects of treatment with NR in a cohort of patients with ataxia-telangiectasia (AT). Journal Metabolites Key Outcomes NR-related pathways and metabolites signi...

Nicotinamide Riboside and Pterostilbene Increase NAD+ Levels in Patients with Acute Kidney Injury: Clinical Findings

Objectives To evaluate the effects of escalating doses of nicotinamide riboside and pterostilbene (NRPT) on blood NAD+ levels and safety outcomes in patients hospitalized with acute kidney injury ...

Nicotinamide Riboside Supplementation Reduces Inflammation in Heart Failure Patients: Clinical Findings

Objectives To investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential anti-inflammatory effe...

Nicotinamide Riboside Supplementation Combined with Metabolic Cofactors Shows Promise for NAFLD: Clinical Findings

Objectives To assess the tolerability and metabolic effects of combined supplementation with combined metabolic activators (CMA), L-serine, NAC, nicotinamide riboside, and L-carnitine in healthy h...

Nicotinamide Riboside Supplementation with Metabolic Cofactors Reduces Liver Fat in NAFLD Patients: Clinical Findings

Objectives To determine if combined metabolic activator supplementation (CMA) will reduce hepatic fat in nonalcoholic fatty liver disease (NAFLD) patients. Journal Molecular Systems Biology Key O...

Nicotinamide Riboside Supplementation Modestly Improves Body Composition & Sleeping Metabolic Rate: Clinical Findings

Objectives To investigate the effects of NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers. Journal The Am...

The Effects of NAD+ Boosting on Muscle Mitochondrial Function: Clinical Findings

Objectives To determine if NR supplementation in middle-aged, obese, insulin-resistant men affects mitochondrial respiration, content and morphology in skeletal muscle. Journal The Journal of Phys...

Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Objectives To establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD+ metabolome and if it can alter muscle mitochondrial bioenergetics. Journal Cell R...

The Effects of NAD+ Boosting on Glucose Metabolism or Hormone Response: Clinical Findings

Objectives To test whether NAD+ precursor supplementation with NR affects β-cell function, α-cell function, and incretin hormone secretion as well as circulating bile acid levels in humans. Journa...

Nicotinamide Riboside Supplementation Increases NAD+ Levels in Humans: Clinical Findings

Objectives To evaluate the safety and efficiacy of NR supplementation in overweight, but otherwise healthy men and women. Journal Scientific Reports Key Outcomes NR supplementation significantly ...

Nicotinamide Riboside Improves Redox Balance and Muscle Performance: Clinical Findings

Objectives To investigate the effects of acute NR supplementation on redox homeostasis and exercise performance in young and old humans. Journal European Journal of Nutrition Key Outcomes Within ...

Nicotinamide Riboside and Pterostilbene Slow Disease Progression in ALS Patients: Clinical Findings

Objectives To assess the safety, tolerability, and efficacy of nicotinamide riboside and pterostilbene (NRPT) supplementation in people with amyotrophic lateral sclerosis (ALS). Journal Amyotrophi...

High-Dose Nicotinamide Riboside Supplementation Is Safe and Effective: Clinical Findings

Objectives To test the safety of NR supplementation and its potential to improve insulin sensitivity and other metabolic parameters in obese, insulin-resistant men. Journal The American Journal of...

Nicotinamide Riboside Supplementation Safely Boosts NAD+ in Middle-Aged and Older Adults: Clinical Findings

Objectives To assess the tolerability and efficacy of chronic NR supplementation on increasing NAD+ levels in healthy middle-aged and older adults. Journal Nature Communications Key Outcomes NR ...

Nicotinamide Riboside Supplementation Increases Blood NAD+ Levels in Healthy Humans: Clinical Findings

Objectives To determine the human pharmacokinetics of NR supplementation and its effect on whole blood nicotinamide adenine dinucleotide (NAD+) levels. Journal PLoS ONE Key Outcomes NR supplement...

Nicotinamide Riboside and Pterostilbene Safely Elevate NAD+ Levels in Humans: Clinical Findings

Objectives To evaluate the safety, tolerability, and efficacy of nicotinamide riboside and pterostilbene (NRPT) supplementation on sustaining elevated whole-blood NAD+ levels in healthy older adul...

Nicotinamide Riboside Supplementation Is Orally Bioavailable in Both Mice and Humans: Clinical Findings

Objectives To determine the time and dose-dependent effects of NR supplementation on blood NAD+ metabolism in humans. Journal Nature Communications Key Outcomes Single oral doses of NR significan...