Article: Nicotinamide Riboside Supplementation Improves Neurological Scores and Markers of Immune Health in Ataxia Telangiectasia: Clinical Findings

Sep 13, 2021 Ataxia Telangiectasia Clinical Neurological Health

Nicotinamide Riboside Supplementation Improves Neurological Scores and Markers of Immune Health in Ataxia Telangiectasia: Clinical Findings

Objectives

To investigate the effects of NR supplementation in patients with ataxia telangiectasia (AT).

Journal

Movement Disorders

Key Outcomes

NR supplementation improved ataxia scores (SARA and ICARS). However, this improvement disappeared after NR withdrawal, indicating a temporary, symptomatic effect of NR in AT.
NR also markedly increased serum immunoglobulin G (IgG) in immunodeficient patients.
This is the first clinical study to investigate the effects of NR in patients with AT, and most notably, the first clinical NR trial in children under the age of 18.

Duration

4 months

Dose

25 mg/kg

Study Design

Open-label proof-of-concept study in 24 patients with ataxia telangiectasia (AT)

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