Beyond Pellagra—NAD+ Deficiency in Aging and Disease: Review

Synopsis

Interest in NAD+ has surged because low NAD+ levels are linked to many health problems, including metabolic diseases, neurodegeneration, reproductive disorders, cancer, and aging. Researchers are now focusing on moderate but still harmful NAD+ deficiencies, not just severe cases like pellagra. This includes developing accurate models to study NAD+ biology and testing new ways to boost NAD+ inside cells. This review summarizes early landmark research, new experimental systems for studying NAD deficiency, and emerging strategies to restore healthy NAD+ levels.

JOURNAL

Cells

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Alzheimer's Disease

Nicotinamide Riboside Supplementation Combined with Metabolic Activators Improves Cognitive Function in Alzheimer’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of L-carnitine tartrate, nicotinamide riboside (NR), serine, and N-acetyl-L-cysteine (NAC), coul...

Clinical

Nicotinamide Riboside Supplementation Does Not Disrupt Methylation, Including in Individuals with MTHFR Mutations: Clinical Findings

Objectives To investigate the impact of NR supplementation on DNA methylation patterns in the blood cells and muscle tissues of newly diagnosed, dopaminergic treatment-naïve Parkinson's disease (P...

Beyond Pellagra—NAD+ Deficiency in Aging and Disease: Review

Synopsis

JOURNAL

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