Article: Newly Discovered NADase Enzyme and Nicotinamide Riboside Regulate NAD+ Levels and Red Blood Cell Production: Preclinical Findings

Apr 23, 2014 Cellular Health Preclinical

Newly Discovered NADase Enzyme and Nicotinamide Riboside Regulate NAD+ Levels and Red Blood Cell Production: Preclinical Findings

Synopsis

NADases are enzymes that break down NAD+ into smaller molecules, but their exact role isn't clear. This study found a new NADase on the surface of rabbit red blood cell precursors. It is attached to the cell membrane and has sugar molecules (glycosylated). When the enzyme was reduced in bone marrow cells, fewer red blood cells were made, and NAD+ levels inside the cells went up. Giving cells extra NAD+ or its precursors—nicotinamide and nicotinamide riboside—also lowered red blood cell production. This suggests that this NADase helps control red blood cell development by managing NAD+ levels in blood stem cells.

Journal

Journal of Biological Chemistry

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Newly Discovered NADase Enzyme and Nicotinamide Riboside Regulate NAD+ Levels and Red Blood Cell Production: Preclinical Findings

Synopsis

Journal

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