Article: Nicotinamide Riboside Enhances Mitochondrial Function and Extends Lifespan: Preclinical Findings

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Healthy Aging & Longevity Mitochondrial Health Preclinical

Nicotinamide Riboside Enhances Mitochondrial Function and Extends Lifespan: Preclinical Findings

Synopsis

NAD+ is a vital molecule that maintains metabolic balance and fuels sirtuin enzymes, which help regulate aging and energy use. In this study, researchers found that NAD+ levels decline with age in both mice and the roundworm C. elegans, and that further reducing NAD+ shortens lifespan in worms. Restoring NAD+ levels—either through genetics or drugs—helped prevent age-related metabolic decline and extended lifespan, effects that depended on the sirtuin protein sir-2.1. This restoration also triggered beneficial stress responses, including the mitochondrial unfolded protein response (UPRmt) and activation of the longevity-related transcription factor DAF-16/FOXO. Overall, the findings suggest that boosting NAD+ can enhance mitochondrial function and stress resilience, offering a promising approach to delay or treat age-related decline.

Journal

Cell

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