Nicotinamide Riboside Demonstrates Cardioprotective Effects by Boosting Mitochondrial Stress Response: Preclinical Findings

Synopsis The mitochondrial unfolded protein response (UPRmt) helps cells manage misfolded proteins in mitochondria to maintain function. Cardiac mitochondria are essential for contractile function...

Nicotinamide Riboside Supplementation and Exercise Are Safe and Feasible in Childhood Cancer Survivors: Clinical Findings

Objectives To evaluate the feasibility and efficacy of a remote telehealth exercise program, with or without NR supplementation, on improving glucose homeostasis and muscle health in adult childho...

Nicotinamide Riboside Supplementation Increases Muscle Mitochondrial Biogenesis & Gut Health: Clinical Findings

Objectives To investigate the effects of long-term NR supplementation on mitochondrial biogenesis and metabolic health in humans. Journal Science Advances Key Outcomes In the BMI-discordant twin...

Short-Term Nicotinamide Riboside Supplementation Increases Muscle NAD+ Flux: Clinical Findings

Objectives To assess the effects of NR supplementation on whole-body metabolism and exercise-induced mitochondrial signaling in the skeletal muscle of healthy adults. Journal The Journal of Physi...

Nicotinamide Riboside Supplementation Modestly Improves Body Composition & Sleeping Metabolic Rate: Clinical Findings

Objectives To investigate the effects of NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers. Journal The Am...

Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Objectives To establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD+ metabolome and if it can alter muscle mitochondrial bioenergetics. Journal Cell R...