Nicotinamide Riboside Reduces Brain Inflammation, Protects Muscle Health, and Enhances Weight Loss in Obesity: Preclinical Findings

Synopsis Obesity treatments like calorie restriction (CR) often cause muscle loss and increase brain inflammation, which can interfere with weight control. In this study, obese rats were given CR,...

Nicotinamide Riboside Mitigates Cancer Cachexia: Preclinical Findings

Synopsis Cancer cachexia, a severe condition seen in advanced cancer patients, causes muscle loss, weight loss, and fat breakdown, greatly reducing quality of life and survival. This study found t...

Nicotinamide Riboside-Supplemented Diet Delays Muscle Degeneration in Mice Lacking the NAMPT Gene: Preclinical Findings

SynopsisNAD+ helps enzymes keep energy balanced in cells, and the enzyme NAMPT controls how NAD+ is made. NAD+ is important for healthy muscle, but how it affects muscle growth isn't fully clear. T...

Nicotinamide Riboside Improves Muscle Quality and Cellular Energy: Preclinical Findings

SynopsisNAD+, crucial for mitochondrial energy production, declines with age, potentially reducing physical performance. This study tested short-term NR supplementation in middle-aged mice and its ...

Short-Term Nicotinamide Riboside Supplementation Increases Muscle NAD+ Flux: Clinical Findings

Objectives To assess the effects of NR supplementation on whole-body metabolism and exercise-induced mitochondrial signaling in the skeletal muscle of healthy adults. Journal The Journal of Physi...

Treatment with S-Adenosylmethionine and Nicotinamide Riboside Immune Function in Arts Syndrome: Case Report

Objectives To assess whether co-therapy with S-adenosylmethionine (SAMe) and NR could improve clinical symptoms, immune cell function, and overall well-being in a child with Arts syndrome, beyond ...

Increasing NAD+ Improves Mitochondrial Function and Reduces Age-Related Amyloidosis: Preclinical Findings

Synopsis As we age, our muscles lose their ability to maintain proper protein balance and mitochondrial health, leading to weakness and degeneration. This study found that aging causes amyloid-lik...

Effects of Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy (DMD) causes progressive muscle wasting due to loss of dystrophin. In dystrophin-deficient mice, muscles show depletion of NAD, an important metabolic cofactor...

Nicotinamide Riboside Supplementation Modestly Improves Body Composition & Sleeping Metabolic Rate: Clinical Findings

Objectives To investigate the effects of NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers. Journal The Am...

Activating the NRK Pathway Improves NAD+ Recycling in Muscle Disorders: Preclinical Findings

Synopsis Hexose-6-Phosphate Dehydrogenase (H6PD) produces NADPH inside the endoplasmic/sarcoplasmic reticulum (ER/SR), helping activate glucocorticoid hormones. However, its broader role in mainta...

Nicotinamide Riboside Administration Improves Mitophagy and Slows Aging in Werner Syndrome: Preclinical Findings

Synopsis Werner syndrome (WS) is a premature aging disease caused by mutations in the WRN gene, which affects DNA repair. WS patients show severe metabolic problems, but the causes are not fully c...

Limited Effects of Quercetin and Nicotinamide Riboside in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy causes progressive muscle weakness and damage. Researchers tested quercetin (Q), nicotinamide riboside (NR), lisinopril (Lis), and prednisolone (Pred), alone o...

Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Objectives To establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD+ metabolome and if it can alter muscle mitochondrial bioenergetics. Journal Cell R...

Nicotinamide Riboside Demonstrates Cardioprotective Effects by Boosting Mitochondrial Stress Response: Preclinical Findings

Synopsis The mitochondrial unfolded protein response (UPRmt) helps cells manage misfolded proteins in mitochondria to maintain function. Cardiac mitochondria are essential for contractile function...

Nicotinamide Riboside Rejuvenates Aging Gut Stem Cells: Preclinical Findings

Synopsis Aging leads to tissue decline partly due to reduced function of adult stem cells. In the intestine, the number and activity of intestinal stem cells (ISCs) decrease with age, while Paneth...

Nicotinamide Riboside Improves Redox Balance and Muscle Performance: Clinical Findings

Objectives To investigate the effects of acute NR supplementation on redox homeostasis and exercise performance in young and old humans. Journal European Journal of Nutrition Key Outcomes Within ...

Effects of Nicotinamide Riboside on Energy Metabolism and Exercise Performance: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a form of vitamin B3 that can boost NAD(P) levels, which are important for energy metabolism in cells. While previous studies in older or sick mice showed th...

Nicotinamide Riboside Reduces Alcohol-Related Liver Damage: Preclinical Findings

Synopsis Alcohol causes liver damage by lowering the activity of SIRT1, a protein that regulates fat metabolism and mitochondrial function. Giving mice nicotinamide riboside (NR), an NAD+ precurso...

Nicotinamide Riboside Improves Alzheimer's Features and DNA Repair: Preclinical Findings

Synopsis Alzheimer’s disease (AD) involves problems with energy metabolism and DNA repair, but how these contribute to key AD features is unclear. A DNA repair-deficient AD mouse model (3xTgAD/Pol...

Nicotinamide Riboside Improves Muscle Function in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Neuromuscular diseases such as Duchenne muscular dystrophy (DMD) arise from genetic mutations that cause progressive muscle weakness and degeneration. This study identifies nicotinamide a...