Article: Nicotinamide Riboside Improves Redox Balance and Muscle Performance: Clinical Findings

Feb 6, 2019 Clinical Healthy Aging & Longevity Muscle Health

Nicotinamide Riboside Improves Redox Balance and Muscle Performance: Clinical Findings

Objectives

To investigate the effects of acute NR supplementation on redox homeostasis and exercise performance in young and old humans.

Journal

European Journal of Nutrition

Key Outcomes

Within two hours, NR supplementation increased red blood cell NADH and NADPH levels in both young and older subjects.
In older subjects, NR reduced systemic oxidative stress and showed a trend toward increased glutathione levels.
NR improved muscle performance in older adults, increasing isometric peak torque by 8% and improving resistance to fatigue by approximately 15%, with no benefits seen in younger subjects.
NR did not improve VO₂max or concentric muscle strength in either age group.

Duration

24 hours

Dose

Single dose of 500 mg

Study Design

Randomized, double-blind, placebo-controlled crossover study in 24 healthy young and older men

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