Article: Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Aug 13, 2019 Clinical Inflammation Muscle Health

Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Objectives

To establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD+ metabolome and if it can alter muscle mitochondrial bioenergetics.

Journal

Cell Reports

Key Outcomes

NR supplementation increased the muscle NAD+ metabolome.
NR significantly decreased levels of circulating inflammatory markers (IL-6, IL-5, and IL-2, and TNF-α, compared to baseline).

Duration

3 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled, crossover study in 12 marginally overweight, but otherwise healthy aged men

See Published Study

Clinical

The Effects of NAD+ Boosting on Glucose Metabolism or Hormone Response: Clinical Findings

Objectives To test whether NAD+ precursor supplementation with NR affects β-cell function, α-cell function, and incretin hormone secretion as well as circulating bile acid levels in humans. Journa...

Diabetes

Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice: Preclinical Findings

Synopsis This study tested whether nicotinamide riboside (NR) can reduce brain inflammation and improve cognitive function in diabetic mice. Mice with diet- and chemically-induced diabetes were gi...