Article: Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Aug 13, 2019 Clinical Inflammation Muscle Health

Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Objectives

To establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD+ metabolome and if it can alter muscle mitochondrial bioenergetics.

Journal

Cell Reports

Key Outcomes

NR supplementation increased the muscle NAD+ metabolome.
NR significantly decreased levels of circulating inflammatory markers (IL-6, IL-5, and IL-2, and TNF-α, compared to baseline).

Duration

3 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled, crossover study in 12 marginally overweight, but otherwise healthy aged men

See Published Study

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Nicotinamide Ribosides Improves Aerobic Performance: Preclinical Findings

Synopsis Nicotinamide riboside (NR) is a form of vitamin B3 that helps increase NAD+ and improve mitochondrial function, but its effect on physical fitness is unclear. In a study with sedentary an...