Article: Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Clinical Inflammation Muscle Health

Nicotinamide Riboside Supplementation Increases Muscle NAD+ Metabolome and Reduces Inflammation: Clinical Findings

Objectives

To establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD+ metabolome and if it can alter muscle mitochondrial bioenergetics.

Journal

Cell Reports

Key Outcomes

NR supplementation increased the muscle NAD+ metabolome.
NR significantly decreased levels of circulating inflammatory markers (IL-6, IL-5, and IL-2, and TNF-α, compared to baseline).

Duration

3 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled, crossover study in 12 marginally overweight, but otherwise healthy aged men

See Published Study

Clinical

The Effects of NAD+ Boosting on Glucose Metabolism or Hormone Response: Clinical Findings

Objectives To test whether NAD+ precursor supplementation with NR affects β-cell function, α-cell function, and incretin hormone secretion as well as circulating bile acid levels in humans. Journa...

Metabolic Health

Nicotinamide Riboside Enhances Muscle Growth and Fiber Density in Chicken Embryos: Preclinical Findings

Synopsis Researchers injected nicotinamide riboside (NR) into fertilized chicken eggs to study its effects on muscle growth. NR increased the weight, length, and width of the pectoral muscles in c...