Muscle Loss and Reduced Physical Performance in Emery–Dreifuss Muscular Dystrophy: Preclinical Findings

Synopsis Autosomal Emery–Dreifuss muscular dystrophy (EDMD) is caused by mutations in the lamin A/C gene (LMNA), which encodes nuclear envelope proteins. The disease typically causes muscle wastin...

Nicotinamide Riboside Supplementation Benefits in Werner's Syndrome: Clinical Findings

Objectives To evaluate the safety and efficacy of oral NR supplementation in patients with Werner Syndrome (WS). Journal Aging Cell Key Outcomes NR improved arterial stiffness, as measured by the...

Nicotinamide Riboside Supplementation Enhances Walking Performance in Peripheral Artery Disease: Clinical Findings

Objectives To assess the effects of NR supplementation alone and in combination with resveratrol on the six-minute walk distance in individuals with peripheral artery disease (PAD). Journal Natur...

Role of NAD+ in Aging and Disease: Review

SynopsisNAD+ is a key coenzyme for many physiological reactions, particularly those supporting mitochondrial function. Its decline with aging contributes to chronic conditions like cognitive declin...

Impact of NAD+ Metabolism on Ovarian Aging: Review

SynopsisNAD+ is a key coenzyme for energy production and many other vital cell functions, including metabolism, DNA repair, gene regulation, aging, and immune health. Low NAD+ levels are directly l...

Roles of NAD+ in Health and Aging: Review

SynopsisNAD+ supports essential processes including metabolism, energy production, DNA repair, mitophagy, inflammation control, and brain function, but its levels drop with aging, affecting all rec...

Beyond Pellagra—NAD+ Deficiency in Aging and Disease: Review

SynopsisInterest in NAD+ has surged because low NAD+ levels are linked to many health problems, including metabolic diseases, neurodegeneration, reproductive disorders, cancer, and aging. Researche...

Emerging Role of Nicotinamide Riboside in Health and Diseases: Review

SynopsisAmong NAD⁺ precursors, nicotinamide riboside (NR) stands out for its safety, effectiveness, and oral bioavailability. A newly identified form of vitamin B3, NR boosts NAD+ in cells and has ...

Balancing NAD+ Deficits with Nicotinamide Riboside: Therapeutic Possibilities and Limitations: Review

SynopsisLow NAD+ levels have been linked to many health problems related to aging and lifestyle. Supplements with NAD+ precursors (vitamin B3 forms) may help, and nicotinamide riboside (NR) has sho...

NAD+ Precursors in Health, Disease, and Aging: Review

SynopsisNAD+ is an essential molecule that helps the body make energy, send signals between cells, keep mitochondria healthy, and decide whether cells survive or die. Research shows that NAD+ level...

NAD+ Metabolism and Its Roles in Cellular Processes During Aging: Review

SynopsisNAD+ is crucial for energy production and for enzymes that control DNA repair, gene activity, aging, and immune function. As we age, NAD+ levels drop in many tissues, and this decline is li...

Therapeutic Potential of NAD-Boosting Molecules: Review

SynopsisNicotinamide adenine dinucleotide (NAD+) is best known as a hydrogen carrier in energy-producing reactions, but it also acts as a signaling molecule that controls hundreds of vital processe...

The Biology and Therapeutic Potential of Nicotinamide Riboside and Nicotinamide Mononucleotide: Review

SynopsisResearch on NAD+ biology has surged, especially around two intermediates—nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—which show promise in preventing and treating age-r...

NAD+ in Aging: Molecular Mechanisms and Translational Implications: Review

SynopsisNAD+ is vital for energy production and helping cells adapt to stress, especially in high-energy tissues like the brain. NAD+ levels drop with age, contributing to chronic diseases such as ...

NAD+ Metabolism: Energy Production, Signaling Pathways, and Therapeutic Potential: Review

SynopsisVitamin B3's active forms, NAD+ and NADP+, are essential for energy metabolism, cell protection, and biosynthesis. Modern research shows that fluctuations in NAD+ metabolism activate signal...

NAD+ in Aging, Metabolism, and Neurodegeneration: Review

SynopsisNAD+ is a coenzyme essential for energy production, redox reactions, and as a partner for enzymes like sirtuins and PARPs. Its levels change with age, and altering its production or usage c...

NAD+ Metabolism as a Therapeutic Target for Age-Related Metabolic Diseases: Review

SynopsisNAD+ is a central redox cofactor, but its role in activating sirtuins—a family of NAD-dependent proteins that optimize mitochondrial function—has made it a focus of longevity research. Beca...

NAD+ Metabolism in Health and Disease: Review

SynopsisNicotinamide adenine dinucleotide (NAD+) is a molecule that helps enzymes in energy reactions and is also used by other enzymes involved in DNA repair, cell signaling, and regulating cell h...