Nicotinamide Riboside Prevents Age-Related Hearing Loss: Preclinical Findings

SynopsisAge‐related hearing loss (ARHL) is the most common sensory disability associated with human aging. Yet, there are no approved measures for preventing or treating this debilitating condition...

Impact of Nicotinamide Riboside and β-Hydroxybutyrate on Lifespan: Preclinical Findings

Synopsis Researchers studying the longevity of C. elegans (a model organism for aging research) found that nicotinamide riboside (NR)—a vitamin B3–derived NAD+ booster—and beta-hydroxybutyrate (BH...

Nicotinamide Riboside Restores NAD+ and Improves Survival of Neurons with Autophagy Defects: Preclinical Findings

SynopsisAutophagy is a cellular recycling process vital for neuron survival, and its failure contributes to neurodegenerative diseases. This study generated human neurons lacking the autophagy gene...

Nicotinamide Riboside Supplementation Partially Restores Sense of Smell in Aging: Preclinical Findings

SynopsisLoss of smell is an early and common feature of both aging and neurodegenerative diseases such as Alzheimer's and Parkinson's. This study investigated behavioral and molecular changes in th...

Nicotinamide Riboside Boosts NAD+ to Improve Telomere Stability: Preclinical Findings

SynopsisTelomere biology disorders (TBDs), such as dyskeratosis congenita (DC), are characterized by critically short telomeres and often lead to bone marrow failure. A key metabolic molecule, NAD+...

Beyond Pellagra—NAD+ Deficiency in Aging and Disease: Review

SynopsisInterest in NAD+ has surged because low NAD+ levels are linked to many health problems, including metabolic diseases, neurodegeneration, reproductive disorders, cancer, and aging. Researche...

Nicotinamide Riboside Maintains Mitochondrial Health in Intervertebral Disc Degeneration: Preclinical Findings

Synopsis This study explored how the mitochondrial unfolded protein response (UPRmt) protects cells in the intervertebral disc from damage by activating mitophagy, the process that clears defectiv...

Autophagy Promotes Cell Survival by Maintaining Stable NAD+ Levels: Preclinical Findings

SynopsisAutophagy is a cellular process that removes damaged parts of the cell and is important for healthy aging. When autophagy is lost, NAD+ levels fall due to increased activity of enzymes that...

Comparison of Metformin and Nicotinamide Riboside in Reducing Tissue Aging: Preclinical Findings

SynopsisMetformin (MET) and nicotinamide riboside (NR) both have potential anti-aging effects, but how they work in different tissues isn't fully clear. This study showed that MET and NR reduce sig...

Nicotinamide Riboside Delays Aging in DNA Repair-Deficient Mice: Preclinical Findings

Synopsis Even though cells can repair DNA, damage naturally builds up over time, harming cell function and contributing to aging. Finding ways to prevent DNA damage or improve repair could help ex...

Emerging Role of Nicotinamide Riboside in Health and Diseases: Review

SynopsisAmong NAD⁺ precursors, nicotinamide riboside (NR) stands out for its safety, effectiveness, and oral bioavailability. A newly identified form of vitamin B3, NR boosts NAD+ in cells and has ...

Balancing NAD+ Deficits with Nicotinamide Riboside: Therapeutic Possibilities and Limitations: Review

SynopsisLow NAD+ levels have been linked to many health problems related to aging and lifestyle. Supplements with NAD+ precursors (vitamin B3 forms) may help, and nicotinamide riboside (NR) has sho...

NR and NMN Restore Meibomian Gland Function and Tear Health: Preclinical Findings

Synopsis This study found that increasing NAD+ levels in the eye can help reverse age-related meibomian gland dysfunction, a major cause of dry eye disease in older adults. The meibomian glands, l...

EPB41L4A-AS1 and Nicotinamide Riboside Support Brain Energy and Slow Aging: Preclinical FIndings

Synopsis The long non-coding RNA EPB41L4A-AS1 helps regulate NAD+ and ATP production in the brain, which are critical for energy and cellular function. In aging and Alzheimer's disease, EPB41L4A-A...

Nicotinamide Riboside Improves Blood Cell Formation in Aging and Ataxia Telangiectasia: Preclinical Findings

SynopsisNAD+ supplements can boost mitochondrial health and DNA repair, which benefits stem cells in aging or disease. This study tested nicotinamide riboside (NR) in mice with reduced blood stem c...

NAD+ Precursors in Health, Disease, and Aging: Review

SynopsisNAD+ is an essential molecule that helps the body make energy, send signals between cells, keep mitochondria healthy, and decide whether cells survive or die. Research shows that NAD+ level...

Nicotinamide Riboside Restores NAD+ and Prevents Age-Related Bone Loss: Preclinical Findings

SynopsisAge-related osteoporosis happens because of a decline in osteoblasts—the cells that build bone—and fewer osteoblast progenitor cells, which show signs of aging called senescence. FoxO trans...

17-α-Estradiol Extends Male Mouse Lifespan, While Nicotinamide Riboside Shows No Significant Effect: Preclinical Findings

SynopsisIn genetically diverse mice, the “non-feminizing” estrogen 17-α-estradiol (17aE2) increased median male lifespan by 19% when started at 16 months and by 11% when started at 20 months. It al...

Nicotinamide Riboside Improves Muscle Quality and Cellular Energy: Preclinical Findings

SynopsisNAD+, crucial for mitochondrial energy production, declines with age, potentially reducing physical performance. This study tested short-term NR supplementation in middle-aged mice and its ...

Increasing NAD+ Improves Mitochondrial Function and Reduces Age-Related Amyloidosis: Preclinical Findings

Synopsis As we age, our muscles lose their ability to maintain proper protein balance and mitochondrial health, leading to weakness and degeneration. This study found that aging causes amyloid-lik...