Discovery of Nicotinamide Riboside as a Natural NAD+ Precursor in Humans and Yeast: Preclinical Findings

Synopsis

Nicotinamide adenine dinucleotide (NAD+) is a vital molecule required by all living organisms. It functions both as a coenzyme that supports energy-producing reactions and as a source of chemical groups involved in processes that can slow aging. Historically, scientists identified nicotinic acid and nicotinamide as the main vitamin precursors of NAD+. However, later research in yeast revealed that nicotinamide riboside (NR) is another unexpected precursor for NAD+ production. This discovery led to the identification of specific enzymes, nicotinamide riboside kinases, in both yeast and humans that convert NR into NAD+. Interestingly, NR is also naturally found in milk, suggesting that it could be used as a dietary supplement to boost NAD+ levels and support cellular health in humans.

Journal

Cell