Article: NAD+ Metabolism as a Therapeutic Target for Age-Related Metabolic Diseases: Review

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Healthy Aging & Longevity Metabolic Health Review

NAD+ Metabolism as a Therapeutic Target for Age-Related Metabolic Diseases: Review

Synopsis

NAD+ is a central redox cofactor, but its role in activating sirtuins—a family of NAD-dependent proteins that optimize mitochondrial function—has made it a focus of longevity research. Because sirtuin activity depends on NAD+ availability, increasing NAD+ levels through precursors or by blocking its breakdown (via PARPs or CD38/CD157) can activate these proteins and promote healthy aging. This review examines how NAD+ metabolism interacts with sirtuin function, how NAD+ levels shift in different physiological states, and how manipulating these pathways could serve as a therapeutic strategy.

JOURNAL

Critical Reviews in Biochemistry and Molecular Biology

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NAD+ Metabolism in Health and Disease: Review

SynopsisNicotinamide adenine dinucleotide (NAD+) is a molecule that helps enzymes in energy reactions and is also used by other enzymes involved in DNA repair, cell signaling, and regulating cell h...

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NAD+ in Aging, Metabolism, and Neurodegeneration: Review

SynopsisNAD+ is a coenzyme essential for energy production, redox reactions, and as a partner for enzymes like sirtuins and PARPs. Its levels change with age, and altering its production or usage c...

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