Article: Effects of Nicotinamide Riboside Supplementation on Nerve Fiber Protection and Axon Regeneration: Clinical Findings
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Effects of Nicotinamide Riboside Supplementation on Nerve Fiber Protection and Axon Regeneration: Clinical Findings
Objectives
To investigate whether boosting NAD+ levels through nicotinamide riboside (NR) supplementation can protect against or promote regeneration of small somatic sensory axons in human skin following capsaicin-induced axon degeneration.
Journal
Journal of the Peripheral Nervous System
Key Outcomes
- NR supplementation resulted in a small increase in skin NAD+ levels.
- NR did not prevent capsaicin-induced degeneration of epidermal sensory nerve fibers.
- NR was associated with a modest but statistically significant increase in epidermal sensory nerve fibers at 60 days; however, these findings are preliminary and warrant further validation.
Duration
97 days
Dose
1000 mg
Study Design
Randomized, double-blind, placebo-controlled, phase II study in 45 healthy men and women