Article: Effects of Nicotinamide Riboside in Mild Cognitive Impairment: Clinical Findings

Jul 21, 2026 Clinical Mild Cognitive Impairment Neurological Health

Effects of Nicotinamide Riboside in Mild Cognitive Impairment: Clinical Findings

Objectives

To assess the safety and preliminary effects of NR supplementation on cognition, brain blood flow, and vascular function.

Journal

Alzheimer's & Dementia

Key Outcomes

NR increased blood NAD+ levels by 107.7%.
NR did not improve cognitive function, although exploratory analyses showed potential improvements in blood flow to the left hippocampus, one of the earliest brain regions affected in Alzheimer’s disease.
NR trended toward improvements in diastolic blood pressure and arterial stiffness.

Duration

12 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled, phase II, pilot study in 42 adults with amnestic mild cognitive impairment (MCI)

See Published Study

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