Article: Nicotinamide Riboside Linked to Reduced Inflammatory Gene Activity in Ataxia Telangiectasia: Clinical Findings

Jun 22, 2026 Ataxia Telangiectasia Clinical Neurological Health

Nicotinamide Riboside Linked to Reduced Inflammatory Gene Activity in Ataxia Telangiectasia: Clinical Findings

Objectives

To define molecular signatures of ataxia telangiectasia (AT) and to assess changes in inflammatory gene activity in blood immune cells in response to NR supplementation.

Journal

International Journal of Molecular Sciences

Key Outcomes

NR was linked to reduced activity of genes involved in inflammation and changes in biological networks associated with neurological improvement.

Duration

2 years

Dose

500 mg

Study Design

Molecular analysis of a previously published open-label, single arm, observational intervention study in 10 patients with AT

See Published Study

Clinical

NR and Ketone Salts Help Preserve Brain Myelin in Mild Cognitive Impairment: Clinical Findings

Objectives To determine whether combining ketone salts with NR could improve brain ketone and glucose metabolism in adults with MCI, and assess effects on white-matter structure, cognitive perform...