Article: Nicotinamide Riboside Reduces Inflammation in Psoriasis: Clinical Findings

Apr 28, 2026 Clinical Immune Health Inflammation Psoraisis

Nicotinamide Riboside Reduces Inflammation in Psoriasis: Clinical Findings

Objectives

To investigate the anti-inflammatory effects of NR supplementation in psoriasis and its underlying mechanisms.

Journal

JCI Insight

Key Outcomes

NR increased whole blood NAD+ levels by 147%.
NR reduced the immune responsiveness of Th17—a type of pro-inflammatory immune cell that is a key driver of psoriasis. This effect was linked to activation of the SLIT2-ROBO1 signaling pathway, which helps regulate inflammatory responses.
NR reduced markers of inflammation in whole blood and in human skin-derived dermal fibroblasts

Duration

4 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled pilot study in 27 individuals with mild-to-moderate psoriasis

See Published Study

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Nicotinamide Riboside In Combination with Exercise Improves Cardiopulmonary Fitness in Friedreich's Ataxia: Clinical Findings

Objectives To evaluate the effects of aerobic and resistance exercise training, alone and in combination with NR supplementation, on cardiopulmonary (heart-lung) fitness and blood sugar control in...